ArticleBDJ open2025
Brain mechanisms of oral multisensory processing related to oral health: a systematic review of neuroimaging findings.
Article in BDJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Neural Control of Mastication: Ion-Channel Mechanisms in the Brainstem Central Pattern Generator.Brain sciences · 2026Review
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Authors and funding
2 authors.
Funding
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Abstract
aimOral functions related to eating, including mastication, swallowing, and taste, are fundamentally a multisensory experience that relies on the crossmodal interaction of touch, gustation, temperature, pain, and proprioception. The brain mechanisms of oral multisensory processing related to eating have remained unknown.
methodsThe current systematic review summarizes the findings from neuroimaging studies (mainly functional magnetic resonance imaging) focusing on the interaction of multiple sensory stimuli in human participants. Neuroimaging studies of human adults on the interaction between multiple sensory stimuli related to oral functions were identified and extracted via three electronic databases and reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
resultsThirteen primary studies were eligible to be included in this review. Five studies investigated the interaction of intraoral (i.e., sensorimotor, taste, and noxious) stimuli. Six studies investigated the interaction between intraoral and extraoral (i.e., auditory, olfactory, and visual) stimuli. One study investigated the audio-visual interaction on dental fear, and another study investigated sensorimotor processing of eating tools. The studies showed great diversity in the experimental design of crossmodal interaction. Regarding the brain features related to the interaction, the somatosensory and motor regions were mostly reported in the studies.
conclusionsThe systematic review revealed a complex pattern of brain activation of oral multisensory processing, which can be attributed to the diversity in the experimental design of crossmodal interaction. The findings highlight the role of multisensory integration in maintaining oral health.
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Registered trials
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