ArticleNature2025
A human-specific enhancer fine-tunes radial glia potency and corticogenesis.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- A Human Accelerated Region Drives Opposing Heterochronic Changes in Craniofacial and Limb Development.bioRxiv : the preprint server for biology · 2026Article
- Early fate diversification of radial glial progenitors during corticogenesis.Science advances · 2026Article
- Interspecific diversity in the neuronal composition of the mammalian cortex arises from heterochrony in neurogenesis.The EMBO journal · 2026Article
- Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors.bioRxiv : the preprint server for biology · 2026Article
- A human-specific microRNA controls the timing of excitatory synaptogenesis.Nature communications · 2026Article
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- Species-specific chromatin architecture and neurogenesis mediated by a human enhancer.Cell stem cell · 2026Article
- Pluripotent stem cells-based neural organoids for modelling human brain development and diseases.Cell & bioscience · 2025Review
- Shaping the Neocortex: Radial Glia and Astrocytes in Development and Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Article
- Novelty versus innovation of gene regulatory elements in human evolution and disease.Current opinion in genetics & development · 2025Review
- The cost of language: functionally over-dominant language circuits in the human brain may limit cognitive abilities and non-verbal executive functions.Frontiers in human neuroscience · 2025Article
- Reconstructing human-specific regulatory functions in model systems.Current opinion in genetics & development · 2024Review
- How our brains are built: emerging approaches to understand human-specific features.Current opinion in genetics & development · 2024Review
- Human-specific genetic modifiers of cortical architecture and function.Current opinion in genetics & development · 2024Review
- Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
15 authors.
Jing LiuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Federica MostiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Hanzhi T ZhaoDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Davoneshia LollisDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Jesus E Sotelo-FonsecaDepartment of Biology, Duke University, Durham, NC, USA.
Carla F Escobar-TomlienovichDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Camila M MussoDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Yiwei MaoDepartment of Cell Biology, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-5202-2648
Abdull J MassriDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0003-1314-6650
Hannah M DollDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0009-0001-6685-9569
Nicole D MossDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
Andre M M SousaDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-1740-5066
Gregory A WrayDepartment of Biology, Duke University, Durham, NC, USA.ORCID 0000-0001-5634-5081
Ewoud R E SchmidtDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0003-4654-2377
Debra L SilverDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA. debra.silver@duke.edu.ORCID 0000-0001-9189-844X
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MThe Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5MMechanisms of neural progenitor division in the developing brainR01NS083897 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2013 to 2023
$3.4MInvestigating sex differences in DDX3X mouse modelsR01NS120667 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA L. · 2021 to 2025
$3.4MRoles for uniquely human enhancers in brain development and WNT signalingR01MH132089 · NIMH · DUKE UNIVERSITY · PI Debra L. Silver · 2023 to 2026
$2.6MDistal mRNA localization and translation in neural stem cells of the developing brainR37NS110388 · NINDS · DUKE UNIVERSITY · PI Debra L. Silver · 2024 to 2026
$2.2MDistal mRNA localization and translation in neural stem cells of the developing brainR01NS110388 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA · 2018 to 2022
$1.8MThe Role of Human SRGAP2C in Regulating Neuronal Circuit Function and BehaviorR00NS109323 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SCHMIDT, EWOUD · 2022 to 2024
$740kNIGMS NIH HHS P20 GM148302NIH HHS P51 OD011132NIMH NIH HHS R01 MH132089NINDS NIH HHS R00 NS109323NINDS NIH HHS R01 NS083897NINDS NIH HHS R01 NS110388NINDS NIH HHS R01 NS120667NINDS NIH HHS R37 NS110388
Abstract
Humans have evolved an extraordinarily expanded and complex cerebral cortex associated with developmental and gene regulatory modifications
Indexed as
Cerebral CortexEnhancer Elements, GeneticEpendymoglial CellsNeurogenesisAnimalsCell ProliferationFemaleFrizzled ReceptorsGene EditingGene Knock-In TechniquesHumansMaleMiceNeural Stem CellsNeuronsPan troglodytesFrizzled Receptors
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.