Evidence map›Paper›PMID 40369253›Full record

ArticleClinical rheumatology2025

Characteristics of sarcopenia in patients with rheumatoid arthritis at a central university hospital in Hanoi, Vietnam: a cross-sectional study.

Thu Hoai Pham, Trang Thi Huyen Do, Tam Ngoc Nguyen, Linh Canh Luu, Huong Thi Tran, Thanh Xuan Nguyen, Thu Thi Hoai Nguyen, Huyen Thi Thanh Vu

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Thu Hoai PhamHanoi Medical University, Hanoi, 100000, Vietnam. phamhoaithu@hmu.edu.vn.ORCID http://orcid.org/0000-0002-8108-5020
Trang Thi Huyen DoHanoi Medical University, Hanoi, 100000, Vietnam.
Tam Ngoc NguyenHanoi Medical University, Hanoi, 100000, Vietnam.
Linh Canh LuuHanoi Medical University Hospital, Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi, 100000, Vietnam.
Huong Thi TranHanoi Medical University, Hanoi, 100000, Vietnam.
Thanh Xuan NguyenHanoi Medical University, Hanoi, 100000, Vietnam.
Thu Thi Hoai NguyenHanoi Medical University, Hanoi, 100000, Vietnam.
Huyen Thi Thanh VuHanoi Medical University, Hanoi, 100000, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the prevalence and factors associated with sarcopenia in rheumatoid arthritis (RA) patients at a central university hospital in Hanoi, Vietnam.

methodsPatients with RA aged ≥ 18 were enrolled in this cross-sectional study. Dual-energy X-ray absorptiometry was performed to measure appendicular skeletal muscle (ASM). Assessment of muscle function included hand grip strength (HGS) and gait speed (GS). Sarcopenia was defined according to Asian Working Group for Sarcopenia (AWGS) criteria 2019. RA disease activity was evaluated by disease activity score 28 CRP (DAS28-CRP). Medical history and previous medications including steroids, methotrexate, bDMARDs, clinical characteristics, and comorbidities were also documented. Multivariable adjusted regression was used to examine potential factors associated with sarcopenia in patients with RA.

resultsA total of 156 patients with RA were recruited, out of which the prevalence of sarcopenia was 62.82%. Among the participants, 95.16% had a low appendicular lean mass index (ALMI), 91.67% had low hand grip strength, and 36.54% had slow gait speed. Active RA disease was significantly associated with a higher odd ratio of having sarcopenia, low muscle mass, and low hand grip strength. After adjusting for potential factors, male (aOR 6.66), RA disease activity level (aOR 3.07), and hypertension (aOR 4.06) were statistically independent factors associated with sarcopenia.

conclusionEffective RA management to achieve clinical remission is essential to mitigate sarcopenia risk. Further studies are essential to better understand sarcopenia and improve management in patients with RA. Key Points • Prevalence: Sarcopenia was present in 62.82% of patients with RA, especially in those with higher disease activity. • Risk Factors: Male gender, active disease, and hypertension were associated with sarcopenia. • Inflammation and disease activity: Active RA and elevated CRP levels were linked to reduced muscle mass and strength.

Indexed as

Arthritis, RheumatoidSarcopeniaAbsorptiometry, PhotonAdultAgedCross-Sectional StudiesFemaleHand StrengthHospitals, UniversityHumansMaleMiddle AgedMuscle, SkeletalPrevalenceRisk FactorsSeverity of Illness IndexAssociated factorsPrevalenceRheumatoid arthritisSarcopenia

Identifiers

PMID40369253

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.