ArticleNpj mental health research2025
Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank.
Article in Npj mental health research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Nocturnal Autonomic Dysregulation and Admission-Window Clinical Suicide-Risk Assessment in Hospitalized Children and Adolescents.Journal of clinical medicine · 2026Article
- Autonomic Flexibility and Early Treatment Success: Heart Rate Variability Predicts Remission in First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- Smart Devices and Multimodal Systems for Mental Health Monitoring: From Theory to Application.Bioengineering (Basel, Switzerland) · 2026Review
- Heart-Brain Axis Dysregulation in Depression: Mechanisms and Implications for Neuromodulation.Neuropsychiatric disease and treatment · 2026Review
- Integrating wearable biosensing with clinical interviews for suicide risk detection in adolescents.Digital healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the autonomic nervous system (ANS) in depression and suicidality is multifaceted. This study examined whether distinct electrocardiography based ANS profiles exist, associated with a lifetime/recent at-risk cohort or a resilient group. Using data from 15,768 participants from the UK Biobank, four unique ANS activity patterns related to heart rate variability (HRV) measures were identified. Two specific clusters, both with low HRV, showed different risks: one characterized by high relative sympathetic tonus and lower breathing rate, indicated higher resilience with less likely depressive symptoms and suicidal thoughts whereas another cluster with dominant relative parasympathetic activity and high breathing rate, aligned with greater depression and suicide attempt prevalence, potentially representing a high-risk cluster. Resilience to depression might be defined by different psychophysiological entities and coping strategies, where the resilient cluster might be characterized by cognitive coping strategies, and increased susceptibility might be linked to more rigid maladaptive coping strategies.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.