ArticleMicrobial cell factories2025
Genome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis.
Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Discovery of leucine analogues of tyrocidines and tryptocidines fromSynthetic and systems biotechnology · 2027Article
- Functional diversity and ecological consequences of endophytic Bacillus-plant interactions.Folia microbiologica · 2026Review
- Systems-level genomic and functional characterization of lipopeptide biosurfactant pathways in Bacillus albus MITWPUB5.World journal of microbiology & biotechnology · 2026Article
- Development of surfactin-based nanocarrier for targeted doxorubicin delivery.Scientific reports · 2026Article
- Bacillus-derived antimicrobial peptides as alternatives to antibiotics in poultry: mechanisms, applications, and future prospects- a review.Archives of microbiology · 2026Review
- Self-Assembly of a Therapeutic Peptide Surfactant: A Small-Angle X-ray Scattering Study.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Structure-Activity Relationship and Biosafety of Linear Pentapeptide Analogs Derived from Battacin for Antimicrobial Development.Antibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
9 authors.
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Abstract
backgroundThe Bacillus genus is well known for producing structurally diverse lipopeptides, many of which exhibit remarkable surface-active and bioactive properties, such as surfactin and daptomycin. In recent years, genome mining has emerged as an effective tool for the discovery of novel natural products by predicting biosynthetic gene clusters and linking them to secondary metabolite production. However, the full biosynthetic potential of many Bacillus subtilis strains remains unexplored. Therefore, this study aimed to investigate the biosynthetic potential of an oilfield-isolated Bacillus subtilis strain through genome mining, with the goal of identifying novel lipopeptides with enhanced surface activity.
resultsIn this study, we identified 14 biosynthetic gene clusters, four of which were related to lipopeptide biosynthesis. In addition, a lipopeptide was characterized as a new member of the surfactin family, namely surfactin-C18. The primary structure of surfactin-C18 was determined to be a heptapeptide ring of N-Glu-Leu-Leu-Val-Asp-Leu-Leu-C linked to the longest β-hydroxy fatty acid in the surfactin family, containing 18 carbon atoms. Moreover, we investigated the surface activity of surfactin-C18, measuring its critical micelle concentration and the surface tension to be 1.99 µmol/L and 28.63 mN/m, respectively. The obtained adsorption parameters of surfactin-C18 at the air/liquid interface further explained its enhanced surface activity in comparison with other surfactin homologs and commercial surfactants.
conclusionsTo the best of our knowledge, this is the first report on the structural characterization and surface activity of surfactin-C18. In addition, our findings not only demonstrate the biosynthetic potential of B. subtilis but also highlight the power of the genome mining strategy for discovering novel lipopeptides with industrial applications.
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