ArticleAnimal bioscience2025
Integrated metabolome and immunity analysis of immune-physiological responses in dairy cows under heat stress condition.
Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Nutritional Modulation of Epigenetic Responses to Heat Stress in Farm Animals: Evidence, Limitations and Perspectives.Animals : an open access journal from MDPI · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
objectiveThis study aimed to investigate the metabolic changes and immune responses in Jersey dairy cows under heat stress (HS). The focus was on understanding HS-induced alterations in metabolism and immunity compared to HS-free cows.
methodsProton nuclear magnetic resonance spectroscopy-based metabolomics was performed on rumen fluid, serum, and milk samples which were collected through single sampling from HS-free (n = 9) and HS-exposed (n = 8) Jersey cows. Immune cell proportions and functions in peripheral blood mononuclear cells (PBMC) were analyzed to identify heat-sensitive immunological changes. Correlation analysis was conducted to link immune indicators with serum metabolites.
resultsMetabolomics revealed potential HS biomarkers in biofluids: nicotinate and phenylacetate in rumen fluid; isopropanol in serum; and glycine and trehalose in milk. HS increased B cell and CD4+ T cell populations, as well as Th17 cells and IL-17A expression in PBMCs. Twenty-three metabolites correlated strongly with five immune indicators, with nine metabolites exhibiting a positive correlation and fourteen a negative correlation.
conclusionHS alters the both metabolism and immune cell function in Jersey dairy cows. These findings provide key information for the development of diagnostic methods for HS and nutritional intervention strategies to mitigate HS for dairy cows.
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