ReviewFrontiers in neuroscience2025
Harnessing theta waves: tACS as a breakthrough in alleviating post-stroke chronic pain.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of adjunctive herbal medicine in the management of post-stroke thalamic pain: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Enhancing response inhibition through a novel tES-fNIRS framework.Scientific reports · 2025Trial
- Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double-Blind, Sham-Controlled Trial.CNS neuroscience & therapeutics · 2025Trial
- High-Frequency Spinal Cord Stimulation Modifies Tibial Nerve-Stimulation-Evoked Cortical Theta-Gamma Coupling in Sheep Cortex.The European journal of neuroscience · 2026Article
- The neuro-skeletal crosstalk: Mechanisms, clinical implications, and smart material interventions.Journal of orthopaedic translation · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural oscillations play a critical role in the regulation of brain functions, with theta waves (4-8 Hz) in the sensorimotor cortex significantly influencing pain perception and modulation. These oscillations can modulate pain signal transmission, emotional cognition, and neuroplasticity. Post-stroke chronic pain is a common and complex symptom that imposes significant physiological and psychological burdens on patients. Transcranial alternating current stimulation (tACS), a non-invasive brain stimulation technique, can synchronize specific frequency neural activities, reorganize brain networks, and modulate neuroplasticity by adjusting specific frequency neural oscillations. In recent years, tACS has been widely applied in the research and treatment of various neurological and psychiatric disorders. This study aims to systematically summarize the current research progress on the regulation of θ oscillations in sensorimotor cortex by tACS. By reviewing relevant experimental and clinical studies, we explore the specific mechanisms of θ oscillations in pain perception and modulation and analyze the mechanisms and effects of tACS modulation of θ oscillations. Additionally, we examine the central and peripheral neural mechanisms of post-stroke chronic pain, emphasizing the critical role of the sensorimotor cortex in pain processing. In conclusion, tACS shows potential for modulating sensorimotor cortex θ oscillations and alleviating post-stroke chronic pain. This research provides new insights into the neural modulation mechanisms related to pain and offers potential new directions for developing novel therapies. Future clinical studies and technological optimizations are necessary to ensure the effectiveness and feasibility of tACS in clinical practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.