Evidence mapPaperPMID 40370701Full record

ArticleQatar medical journal2025

Focus on the endocrine system of children born after reproductive technologies in Kazakhstan.

Sevara Ilmuratova, Lyazzat Manzhuova, Aigul Bazarbayeva, Vyacheslav Lokshin, Zhanar Nurgaliyeva, Farida Kussainova

Abstract read
In one paragraph

Article in Qatar medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sevara IlmuratovaDepartment of Science and Consulting, Kazakhstan Medical University KSPH, Almaty, Republic of Kazakhstan.
Lyazzat ManzhuovaDepartment of Science and Postgraduate Education, Scientific Center of Pediatrics and Children's Surgery, Almaty, Republic of Kazakhstan.
Aigul BazarbayevaDepartment of Science and Postgraduate Education, Scientific Center of Pediatrics and Children's Surgery, Almaty, Republic of Kazakhstan.
Vyacheslav LokshinDepartment of Assisted Reproductive Technologies, International Clinical Center for Reproductology PERSONA, Almaty, Republic of Kazakhstan.
Zhanar NurgaliyevaDepartment of Childhood Diseases named after Professor N.A. Barlybaeva, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan.
Farida KussainovaDepartment of Obstetrics and Gynecology, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan*Correspondence: Aigul Bazarbayeva. Email: aigu.bazarbayeva@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Reproductive technologies are used more widely today than ever before. This increase in the use of assisted reproductive technology (ART) is directly related to sociodemographic conditions that result in delayed childbirth among age groups with lower fertility. Infertility affects 17% of married couples, and in some countries 6% of children are born with in vitro fertilization (IVF). In this context, the aspect of the influence of reproductive technologies on hormonal indicators of offspring in relation to anthropometric data remains insufficiently examined. The purpose of this cohort study is to compare the hormonal panel and anthropometric data of ART-conceived children with the corresponding data of children conceived naturally. Methodology: Biochemical tests are used to determine the amount of free triiodothyronine (T3) and total thyroxine (T4), somatotropin, insulin, insulin-like growth factor, glucose, potassium, and sodium cations in blood samples from the experimental and control groups. Results: The results indicate that the use of assisted reproductive technologies neither altered the endocrine panel of the thyroid gland, nor affected other biochemical parameters. Variations in technologies - classical IVF, fresh or frozen embryo transfer, intracytoplasmic sperm injection - also did not affect the quantitative value of the above indicators. Artificial insemination also had no effect on puberty (in both boys and girls). Children born naturally had a greater body weight (3,453 vs 3,160 g, Conclusion: Several relationships between biochemical and anthropometric indicators were identified: the correlation between body weight and blood levels of insulin-like growth factor was statistically significant, positive, and weak. The tbl3 level in the experimental group was found to be statistically significant and directly proportional to body height, and insulin content was inversely proportional to body weight. The data obtained make it possible to verify the safety of using a different range of reproductive technologies.

Indexed as

assisted reproductive technologieschildren's healthIn vitro fertilizationoffspringsomatotropinthyroid-stimulating hormone

Identifiers

PMID40370701
PMCPMC12076018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.