ArticleFrontiers in aging neuroscience2025
Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer's disease biomarkers and brain structure.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Interactions between minimal amount of exercise and low-density lipoprotein cholesterol on incident dementia after stroke.iScience · 2026Article
- Sex Differences in Alzheimer Disease Imaging Biomarkers in a Diverse, Community-Based Cohort.JAMA network open · 2026Article
- Atherosclerosis index and BMI: new predictors of cognitive function in ischemic survivors.Frontiers in nutrition · 2025Article
- Association between the LDL/HDL ratio and sarcopenia in Chinese community-dwelling older adults.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between the low-density lipoprotein/high-density lipoprotein (LDL/HDL) ratio, an indicator of lipid metabolism and assessment of cardiovascular disease (CVD) risk, and Alzheimer's disease (AD) is unclear. Methods: Multivariable Cox regression analyses were used to examine the association of LDL/HDL ratio and the risk of AD. Multiple linear regression and mixed effects models used to assess associations between LDL/HDL and cognitive function, AD pathology, and brain structure. Mediation analyses examined AD pathology's potential mediating role between the LDL/HDL ratio and cognition. Results: Higher LDL/HDL ratio correlated with lower AD risk (HR 0.644 [0.431, 0.962]). In the linear regression analyses, the LDL/HDL ratio were positively associated with cognition. Longitudinally, the LDL/HDL ratio also positively with cognitive measures. Besides, higher LDL/HDL ratio were associated Aβ Conclusion: The LDL/HDL ratio is associated with AD risk, cognition, AD biomarkers and brain structure and can affect cognition by AD biomarkers.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.