ArticleFrontiers in aging neuroscience2025
Relationship between the hemoglobin-to-red cell distribution width ratio and post-stroke cognitive impairment: a prospective study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mechanisms and biomarkers of poststroke cognitive impairment.Neural regeneration research · 2026Article
- Assessment of hemoglobin-to-red cell distribution width ratio to predict all-cause mortality in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.Frontiers in medicine · 2026Article
- Sarcopenia and inflammatory markers in early-stage breast cancer: a retrospective case-control study of NLR, MLR, RDW-CV, and HRR in middle-aged and elderly women.Frontiers in surgery · 2026Article
- Hemoglobin-to-red blood cell distribution width ratio in the relationship between occupational aluminum exposure and cognitive function impairment: a mediation analysis.Frontiers in public health · 2025Article
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Authors and funding
9 authors.
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Abstract
Background: Post-stroke cognitive impairment (PSCI) is one of the main complications after stroke. The association between the hemoglobin-to-red cell distribution width ratio (HRR) and PSCI remains inadequately explored. Consequently, we performed a prospective study to assess whether HRR levels are associated with changes in cognitive function after acute ischemic stroke (AIS). Methods: A total of 296 AIS patients were recruited. HRR was measured within 24 h of admission, and cognitive function was assessed using the Mini-Mental State Examination (MMSE) one month post-onset. Logistic regression analysis was performed to identify independent risk and protective factors for the occurrence of PSCI. Restricted cubic splines (RCS) were used to explore the dose-response relationship between HRR and PSCI. Results: 129 of 296 participants (43.6%) developed cognitive impairment at 1 month. HRR in PSCI group was significantly lower than that in non-cognitive impairment group ( Conclusion: Reduced HRR levels were linked to an increased risk of cognitive impairment, indicating that HRR may serve as a predictive factor for PSCI.
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