ArticleJournal of inflammation research2025
Correlation of Novel Inflammation Index with Postoperative Acute Kidney Injury in Patients with Joint Arthroplasty: A Retrospective Cohort Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Perioperative Inflammatory Biomarkers and Surgical Site Infection After Pelvic and Acetabular Fracture Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Association between systemic inflammatory response index and cardiovascular disease risk in rheumatoid arthritis patients: a machine learning based on US and Chinese cohorts.Clinical rheumatology · 2026Article
- The joint association of insulin resistance index and neutrophil percentage to albumin ratio with acute kidney injury after orthopedic surgery: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Perioperative Flurbiprofen Axetil Administration and Acute Kidney Injury After Non-Cardiac Surgery: A Retrospective Cohort Study.Drug design, development and therapy · 2026Article
- Construction and Validation of a Nomogram Based on Preoperative Inflammatory Indicators for Predicting Acute Kidney Injury After Pancreaticoduodenectomy.Journal of inflammation research · 2026Article
- AISI, SIRI, and MLR in Predicting Surgical Outcomes After Radical Cystectomy: Revisiting Inflammatory Risk Markers.Medicina (Kaunas, Lithuania) · 2025Article
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11 authors.
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Abstract
Background: Acute kidney injury (AKI) is a frequent complication following joint arthroplasty. This study investigated the association between novel inflammation indices and postoperative AKI. Methods: This retrospective cohort study included 1434 patients who underwent hip or knee arthroplasty, with 1225 patients comprising the complete case analysis dataset. The primary analysis was performed using the complete case analysis dataset, while sensitivity analyses were conducted in both the imputed dataset and the dataset excluding patients with abnormal preoperative creatinine. Inflammation indices, including the Systemic Immune-Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were derived from neutrophil, lymphocyte, monocyte, and platelet counts. Multivariate logistic regression and receiver-operating characteristic curve (ROC) analyses were performed to assess predictive performance. The area under the ROC (AUC) was compared using DeLong test. Results: Among 1225 patients in the complete case analysis dataset, 116 (9.47%) developed AKI (Stage I: 59, Stage II: 55, Stage III: 2). Elevated SIRI and MLR were independently associated with increased AKI risk [adjusted OR (95% CI) for Quartile 4 vs Quartile 1: 1.961 (1.070-3.595) and 1.902 (1.043-3.468), respectively]. AISI showed marginal significance [adjusted trend OR (95% CI): 1.192 (0.995-1.428)]. The predictive performance of the basic model (AUC = 0.565) significantly improved after incorporating SIRI, AISI, and MLR (ΔAUC: +0.066, +0.065, +0.070, respectively; all DeLong Conclusion: SIRI, MLR, AISI, and monocyte count may serve as predictive indicators for AKI following joint arthroplasty. Further randomized trials are needed to establish causality.
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