Evidence map›Paper›PMID 40370778›Full record

Observational studyFrontiers in endocrinology2025

Elevated plasma concentrations of lipoprotein (a) are associated with cardiovascular diseases in patients with early-onset type 2 diabetes mellitus.

Juan Zhang, Jingjing Sang, Yanyan Jiang, Yi Zheng, Jing Zhang, Xuesen Liu, Huafeng Qiu, Kaijian Zhao, Hongmei Sun, Yang Yang and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Juan Zhang *Department of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Jingjing Sang *Department of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Yanyan Jiang *Department of Geriatric Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yi ZhengDepartment of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Jing ZhangDepartment of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Xuesen LiuDepartment of Cardiology, Zhumadian Central Hospital, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Huafeng QiuDepartment of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Kaijian ZhaoDepartment of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Hongmei SunSchool of Biological and Food Processing Engineering, Huanghuai University, Zhumadian, China.
Yang YangDepartment of Scientific Research Section, Zhumadian Central Hospital, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Hao ChenDepartment of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.
Lei YangDepartment of Scientific Research Section, The First People's Hospital of Zhumadian, Affiliated Hospital of Huanghuai University, Zhumadian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To ascertain whether vascular complications and high lipoprotein (a) [Lp(a)] concentrations are related in individuals with early-onset type 2 diabetes mellitus (T2DM). Methods: This observational cross-sectional study included 591 individuals with early-onset T2DM who were divided into four groups based on Lp(a) values which was measured using immunoturbidimetry and presented as mg/dL: high, >50; intermediate, 30≤Lp(a)<50; low, 10≤Lp(a)<30; and very low, <10. The relationship between the risk of vascular complications and Lp(a) level was examined using a logistic regression model. Results: The median age of onset for individuals with early-onset T2DM (n=591) was 37 years, duration of diabetes was 12 years, and glycated hemoglobin (HbA1c) level was 8.8%. The median Lp(a) was 10.40 (4.80-21.80) mg/dL, and Lp(a) concentration did not correlate with age, sex, or glycemic control ( Conclusions: In patients with early-onset T2DM, Lp(a) concentration was independently associated with CHD. Lp(a) testing is essential to determine who has a latent high risk of CHD among patients with early-onset T2DM.

Indexed as

BiomarkersCardiovascular DiseasesDiabetes Mellitus, Type 2Lipoprotein(a)AdultAge of OnsetCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsBiomarkersLipoprotein(a)cerebrovascular diseasecoronary heart diseaseearly-onset type 2 diabetes mellituslipoprotein(a)microvascular complications

Identifiers

PMID40370778
PMCPMC12074905

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.