Evidence map›Paper›PMID 40370995›Full record

ArticleACS pharmacology & translational science2025

Enhanced Cholesterol Efflux and Atherosclerosis Regression via CEH Gene Delivery Using Galactose-Functionalized Dendrimeric Nanoparticles.

Huari Kou, Jing Wang, Paul J Yannie, Da Huang, William J Korzun, Genta Kakiyama, Siddhartha S Ghosh, Hu Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huari KouLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.
Jing WangDepartment of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, United States.
Paul J YannieDepartment of Safety and Risk Management, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Da HuangLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.ORCID https://orcid.org/0000-0003-3621-5233
William J KorzunDepartment of Clinical Laboratory Sciences, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Genta KakiyamaDepartment of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, United States.
Siddhartha S GhoshDepartment of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, United States.
Hu YangLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.ORCID https://orcid.org/0000-0003-3030-004X

Funding

Modulating Macrophage Function in Atherosclerosis by Functionalized NanoparticlesR01HL140684 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI GHOSH, SIDDHARTHA S, YANG, HU · 2018 to 2021
$2.5M
BLRD VA I01 BX002297NHLBI NIH HHS R01 HL140684
6 · The paper itself

Abstract

Cholesteryl ester hydrolase (CEH) is a critical enzyme in cholesterol ester hydrolysis, influencing cholesterol metabolism and efflux. This study demonstrates that CEH overexpression promotes free cholesterol efflux from macrophages, thereby reducing the lipid burden in existing atherosclerotic plaques. To enable targeted delivery, galactose-functionalized polyamidoamine (PAMAM) dendrimeric nanoparticles were utilized as nanocarriers for hepatic delivery of the CEH expression vector. The therapeutic potential of CEH plasmid-loaded dendrimeric nanoparticles was evaluated in Ldlr

Identifiers

PMID40370995
PMCPMC12070320

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.