Evidence map›Paper›PMID 40371697›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Activity guided discovery of dual inhibitors of α-glucosidase and β-glucuronidase from the leaves of

Yanxi He, Huanran Xu, Shaoqian Tan, Jing Long, Hui Lei, Ling Xiao, Xiaoyi Qi, Mingming Deng, Xia Xiong, Jingcan You and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yanxi HeThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Huanran XuInnovation Centre of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, Anqing, People's Republic of China.
Shaoqian TanThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Jing LongThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Hui LeiSchool of Pharmacy, Southwest Medical University, Luzhou, People's Republic of China.
Ling XiaoInnovation Centre of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, Anqing, People's Republic of China.
Xiaoyi QiThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Mingming DengThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Xia XiongThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Jingcan YouBasic Medicine Research Innovation Centre for Cardiometabolic Diseases, Ministry of Education, Southwest Medical University, Luzhou, China.
Liangliang ZhuInnovation Centre of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, Anqing, People's Republic of China.
Muhan LüThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Sicheng LiangThe Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) and cancers are two globally prevalent diseases which can increase the incidence of each other. Intestinal α-glucosidase and β-glucuronidase are key targets for glycaemic control and chemotherapy detoxification, respectively. This study first found that the leaf methanol extract of

Indexed as

alpha-GlucosidasesDrug DiscoveryGlucuronidaseGlycoside Hydrolase InhibitorsIsoflavonesMillettiaPlant ExtractsPlant LeavesDose-Response Relationship, DrugMolecular Docking SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesGlucuronidaseGlycoside Hydrolase InhibitorsIsoflavonesPlant Extractsactive constituentdual inhibitorMillettia pachycarpaα-glucosidaseβ-glucuronidase

Identifiers

PMID40371697
PMCPMC12082738

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.