ArticleAntimicrobial agents and chemotherapy2025
Propranolol is efficacious against
Michael E Zegans, Manali M Kamath, Jane T Jones, Ruina Bao, Brandon S Ross, Cecilia Gutierrez-Perez, Emily M Adams, Jorge D Lightfoot, Galini Poimenidou, Chetan Pavuluri and 3 more
Abstract read
In one paragraphArticle in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Michael E Zegans *Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-6029-9855 Manali M KamathDeparment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jane T JonesDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Ruina BaoDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Brandon S RossDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Cecilia Gutierrez-PerezDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-9808-0701 Emily M AdamsDepartment of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-4382-6166 Jorge D LightfootDepartment of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Galini PoimenidouDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Chetan PavuluriDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Venkatesh PrajnaDepartment of Cornea, Aravind Eye Hospital, Madurai, India.
Robert A Cramer *Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0001-5503-5006 Kevin K Fuller *Deparment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0009-0000-0762-317X Funding
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9MP30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5MOptimization and chemical biology of novel antifungals to combat azole resistant mould infectionsR01AI181215 · NIAID · DARTMOUTH COLLEGE · PI Robert Andrew Cramer · 2024 to 2026
$2.3MThe unfolded protein response as a therapeutic target for fungal keratitisR01EY033866 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kevin K. Fuller · 2022 to 2026
$1.9MDartmouth Cystic Fibrosis Training ProgramT32HL134598 · NHLBI · DARTMOUTH COLLEGE · PI George A. O'Toole · 2017 to 2026
$1.7MVision Science Training ProgramT32EY023202 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2014 to 2025
$952kCystic Fibrosis Foundation 005808G223National Heart Lung & Blood Institute T32 HL134598-03National Institute of Allergy and Infectious Diseases R01AI181215NEI NIH HHS EY02877-01NEI NIH HHS P30 EY021725NEI NIH HHS P30EY021725NEI NIH HHS R01 EY033866NEI NIH HHS R01EY033866NEI NIH HHS T32 EY023202NEI NIH HHS T32EY023202NHLBI NIH HHS T32 HL134598NIAID NIH HHS R01 AI181215NIGMS NIH HHS P20 GM113132Research to Prevent Blindness
6 · The paper itselfAbstract
Fungal keratitis is a severe corneal infection most commonly caused by filamentous fungi. Even with prompt treatment with current antifungals, it often results in corneal perforation and blindness. In this report, we observe that the beta-adrenergic antagonist, propranolol, displays antifungal activity against
Indexed as
Adrenergic beta-AntagonistsAntifungal AgentsAspergillosisAspergillus fumigatusEye Infections, FungalFusariosisFusariumKeratitisPropranololAnimalsClinical Trials, Phase III as TopicCorneaDisease Models, AnimalFemaleHumansMiceAdrenergic beta-AntagonistsAntifungal AgentsPropranololantifungal agentsAspergillusfungal keratitisFusariumkeratitispropranolol
Identifiers
PMID40372030
PMCPMC12135505
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