Evidence map›Paper›PMID 40372152›Full record

ArticleACS chemical neuroscience2025

Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D

Herman D Lim, Damian Bartuzi, Alastair C Keen, Caroline Rauffenbart, Jacqueline Glenn, Steven J Charlton, Silvia Lovera, Zara A Sands, Ali Ates, Martyn Wood and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  3. Bitopic AJournal of medicinal chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Herman D LimDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 399 Royal Parade, Parkville, VIC 3052, Australia.
Damian BartuziScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala SE- 751 24, Sweden.ORCID 0000-0001-9927-376X
Alastair C KeenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 399 Royal Parade, Parkville, VIC 3052, Australia.ORCID 0000-0002-0036-757X
Caroline RauffenbartDepartments of Psychiatry and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, United States.
Jacqueline GlennDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
Steven J CharltonDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.ORCID 0000-0001-8841-2752
Silvia LoveraUCB BioPharma SPRL, Chemin de Foriest, Braine-l'Alleud, Brussels B-1420, Belgium.
Zara A SandsUCB BioPharma SPRL, Chemin de Foriest, Braine-l'Alleud, Brussels B-1420, Belgium.
Ali AtesUCB BioPharma SPRL, Chemin de Foriest, Braine-l'Alleud, Brussels B-1420, Belgium.
Martyn WoodUCB BioPharma SPRL, Chemin de Foriest, Braine-l'Alleud, Brussels B-1420, Belgium.
Meritxell CanalsDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.ORCID 0000-0002-7942-5006
Jonathan A JavitchDepartments of Psychiatry and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, United States.
Jens CarlssonScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala SE- 751 24, Sweden.ORCID 0000-0003-4623-2977
J Robert LaneDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom.ORCID 0000-0002-7361-7875

Funding

Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
NIMH NIH HHS R01 MH054137
6 · The paper itself

Abstract

Recently, the first small-molecule positive allosteric modulators (PAMs) of the dopamine D

Indexed as

Receptors, Dopamine D2Allosteric RegulationAllosteric SiteAnimalsBinding SitesDopamineDopamine AgonistsHEK293 CellsHumansMolecular Dynamics SimulationMutagenesis, Site-DirectedDopamineDopamine AgonistsReceptors, Dopamine D2allosteric sitedopamine D2 receptorG protein-coupled receptorpositive allosteric modulator

Identifiers

PMID40372152
PMCPMC12186844

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.