Evidence map›Paper›PMID 40372500›Full record

ArticleSurgery today2025

Impact of the log odds of positive lymph nodes on the prognosis in pathological stage 3 patients with obstructive colorectal cancer treated with colonic stents: a retrospective multicenter study in Japan.

Toshio Shiraishi, Tetsuro Tominaga, Takashi Nonaka, Yuma Takamura, Kaido Oishi, Shintaro Hashimoto, Keisuke Noda, Rika Ono, Makoto Hisanaga, Akiko Fukuda and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgery today, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Toshio ShiraishiDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Tetsuro TominagaDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. tetsuro.tominaga@nagasaki-u.ac.jp.
Takashi NonakaDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Yuma TakamuraDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Kaido OishiDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Shintaro HashimotoDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Keisuke NodaDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Rika OnoDepartment of Surgery, Sasebo City General Hospital, 9-3 Hirase, Sasebo, Nagasaki, 857-8511, Japan.
Makoto HisanagaDepartment of Surgery, Sasebo City General Hospital, 9-3 Hirase, Sasebo, Nagasaki, 857-8511, Japan.
Akiko FukudaDepartment of Surgery, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki, 856-8562, Japan.
Masaaki MoriyamaDepartment of Surgery, Isahaya General Hospital, 24-1 Eisyohigashi, Isahaya, Nagasaki, 854-8501, Japan.
Fumitake UchidaDepartment of Surgery, Ureshino Medical Center, 4279-3 Ureshino, Ureshino, Saga, 843-0393, Japan.
Kazuki MotoyamaDepartment of Surgery, Saiseikai Nagasaki Hospital, 2-5-1 Katafuchi, Nagasaki, Nagasaki, 850-0003, Japan.
Masaki KunizakiDepartment of Surgery, Sasebo Chuo Hospital, 15 Yamato, Sasebo, Nagasaki, 857-1195, Japan.
Keitaro MatsumotoDepartment of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study investigated the relationship between log odds of positive lymph nodes (LODDS) and the long-term prognosis in pathological stage 3 obstructive colorectal cancer (CRC) patients who underwent self-expandable metal stent (SEMS) insertion as a bridge to surgery (BTS).

methodsThis retrospective multicenter study included 75 patients with stage 3 CRC. The patients were classified into high-LODDS (LODDS-H, n = 32) and low-LODDS (LODDS-L, n = 43) groups.

resultsSignificant differences were found in the 5-year relapse-free survival (RFS) rates (LODDS-H: 34.0% vs. LODDS-L: 53.1%; p = 0.041) and overall survival (OS) rates (52.4% vs. 68.3%; p = 0.012). A multivariate analysis revealed that blood loss [hazard ratio (HR) 2.266, 95% confidence interval (CI), 1.142-4.494; p = 0.019] was an independent predictor of the RFS. Age ≥ 75 years old (HR 2.769, 95% CI 1.206-6.360; p = 0.016), blood loss (HR 3.552, 95% CI 1.460-8.643; p = 0.005), adjuvant chemotherapy (HR 0.415, 95% CI 0.177-0.972; p = 0.043), and LODDS (HR 3.593, 95% CI 1.511-8.544; p = 0.004) were independent predictors of OS.

conclusionsThe LODDS appears to be prognostically accurate for patients with stage 3 obstructive CRC undergoing BTS. Incorporating the LODDS into clinical evaluations may enable more accurate prognostic stratification.

Indexed as

Colorectal NeoplasmsIntestinal ObstructionLymph NodesSelf Expandable Metallic StentsStentsAgedAged, 80 and overAge FactorsFemaleHumansJapanLymphatic MetastasisMaleMiddle AgedNeoplasm StagingOdds RatioColonic stentColorectal cancerLog odds of positive lymph nodes

Identifiers

PMID40372500

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.