Evidence map›Paper›PMID 40374208›Full record

ArticleBMJ open ophthalmology2025

Associations between measures of oestrogen exposure and severity of Fuchs endothelial corneal dystrophy.

Redion B Petrela, Chandra Divyash Chhetri, Ahmad Najafi, Zhaoqi Zhang, Tommy A Rinkoski, Eric D Wieben, Michael P Fautsch, Saptarshi Chakraborty, Amy E Millen, Sangita P Patel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Redion B PetrelaOphthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Chandra Divyash ChhetriOphthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
Ahmad NajafiOphthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.ORCID 0000-0002-7468-2935
Zhaoqi ZhangBiostatistics, University at Buffalo, Buffalo, New York, USA.
Tommy A RinkoskiOphthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Eric D WiebenBiochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.
Michael P FautschOphthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Saptarshi ChakrabortyBiostatistics, University at Buffalo, Buffalo, New York, USA.
Amy E MillenEpidemiology and Environmental Health, University at Buffalo School of Public Health and Health Professions, Buffalo, New York, USA.
Sangita P PatelOphthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA sppatel@buffalo.edu.ORCID 0000-0001-6969-490X

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Sex disparity and estradiol in Fuchs' endothelial corneal dystrophyK08EY029007 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PATEL, SANGITA · 2018 to 2022
$855k
NCATS NIH HHS UL1 TR001412NEI NIH HHS K08 EY029007
6 · The paper itself

Abstract

aimsTo determine the associations between measures of oestrogen exposure and Fuchs endothelial corneal dystrophy (FECD) severity.

methodsClinic-based cross-sectional study of 32 postmenopausal women and 11 men with mild or severe FECD, age>55 years. Participants completed questionnaires for data on demographics, anthropometric factors, medical history and potential risk factors for FECD. Women completed an additional reproductive history questionnaire used to calculate the months of lifetime oestrogen exposure. Slit-lamp biomicroscopy, specular microscopy, corneal Scheimpflug tomography and laboratory testing (

results43 patients were enrolled in the study (mild FECD: 17 women, 3 men; severe FECD: 15 women, 8 men). Serum-free estradiol was higher in the severe compared with mild FECD group (0.21±0.2 vs 0.09±0.1 pg/mL; p=0.046). When stratified by sex, men showed no significant associations between oestrogen measures and FECD severity. However, in women, the odds of severe FECD were increased with more months of lifetime oestrogen exposure (all women; log OR (95% credible interval): 1.3 (0.14 to 4.3)), higher concentrations of free estradiol (all women; 2.1 (0.0049 to 10)), greater % free estradiol (only women without

conclusionsWhile the application of these data is constrained by the limited number of participants, a clinic-based sample, small number of men compared with women and single-point measures of serum hormone measures, these data suggest that FECD severity is associated with higher oestrogen exposures in women but not men and may be dependent on

Indexed as

EstradiolEstrogensFuchs' Endothelial DystrophyAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPostmenopauseRisk FactorsSeverity of Illness IndexSex Hormone-Binding GlobulinSurveys and QuestionnairesTranscription Factor 4EstradiolEstrogensSex Hormone-Binding GlobulinTCF4 protein, humanTranscription Factor 4Cornea

Identifiers

PMID40374208
PMCPMC12083347

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.