Evidence map›Paper›PMID 40374883›Full record

ArticleScientific reports2025

Antiparasitic efficacy of geraniol from Apiaceae family in scabies treatment.

Iman S A Khallaf, Lourin G Malak, Soad A L Bayoumi, Salwa F Farag, Ahmed M Sayed, Sara A Mohamed, Asmaa A E Nasr, Radwa Y Ibrahim, Eman Maher Zahran, Gerhard Bringmann and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Iman S A KhallafPharmacognosy and Natural Products Department, Faculty of Pharmacy, Menoufia University, Shibin Elkom, 32511, Egypt. Iman.Khallaf123@phrm.menofia.edu.eg.
Lourin G MalakPharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Soad A L BayoumiPharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Salwa F FaragPharmacognosy Department, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
Ahmed M SayedDepartment of Pharmacognosy, College of Pharmacy, Almaaqal University, Basrah, 61014, Iraq.
Sara A MohamedDepartment of Parasitology, Faculty of Veterinary Medicine, Assiut University, Assiut, 71515, Egypt.
Asmaa A E NasrDepartment of Poultry Diseases, Animal Health Research Institute, Assiut Regional Laboratory, Agricultural Research Center (ARC), Assiut, Egypt.
Radwa Y IbrahimDepartment of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Eman Maher ZahranDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, 7 Universities Zone, New Minia City, 61111, Egypt.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Deraya University, 7 Universities Zone, New Minia City, 61111, Egypt. usama.ramadan@mu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcoptic mange, commonly known as scabies, is a highly contagious skin condition caused by the burrowing mite Sarcoptes scabiei (Astigmata: Sarcoptinae). This parasitic disease significantly impacts livestock and human health, particularly in underserved regions. Current treatments rely on synthetic acaricides like permethrin and ivermectin, which suffer from limitations such as toxicity, resistance development, and environmental contamination. Essential oils from Apiaceae plants represent a promising natural alternative. This study reviewed 122 volatile constituents from Apiaceae plants and conducted comprehensive in silico analyses to identify potential antiparasitic agents. Geraniol emerged as a potent acaricidal candidate due to its strong binding affinity to acetylcholinesterase (AChE) (docking score: - 7.85 kcal/mol). In vitro testing revealed geraniol achieved a 100% mite mortality rate at concentrations as low as 6.25% within 15 min (LT

Indexed as

AcaricidesAcyclic MonoterpenesAntiparasitic AgentsSarcoptes scabieiScabiesTerpenesAnimalsHumansRabbitsAcaricidesAcyclic MonoterpenesAntiparasitic AgentsgeraniolTerpenesAcaricidal activityAcetylcholinesteraseApiaceaeGeraniolIn silico analysis

Identifiers

PMID40374883
PMCPMC12081939

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.