Evidence map›Paper›PMID 40375438›Full record

ArticleRedox report : communications in free radical research2025

The PKC/NOX/ROS and PYK2/MEK/ERK/PARP signalling pathways drive TRPM2 channel activation induced by non-cytolytic oxidative stress in microglial cells.

Sharifah Alawieyah Syed Mortadza, Nur Zulaikha Mohamad Zahir, Chew Tze Wei, Lin-Hua Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sharifah Alawieyah Syed MortadzaSino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang, People's Republic of China.
Nur Zulaikha Mohamad ZahirDepartment of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
Chew Tze WeiDepartment of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
Lin-Hua JiangSino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang, People's Republic of China.ORCID 0000-0001-6398-0411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe study aimed to investigate the signalling mechanism for TRPM2 channel activation by non-cytolytic oxidative stress in microglia.

methodsMicroglia from wild-type (WT) and TRPM2-knockout (KO) mice were exposed to 10-30 mM H

resultsExposure of WT microglia to H

conclusionOur results support that PKC/NOX-mediated ROS generation and TRPM2-mediated Ca

Indexed as

MicrogliaOxidative StressTRPM Cation ChannelsAnimalsFocal Adhesion Kinase 2Hydrogen PeroxideMAP Kinase Signaling SystemMiceMice, KnockoutNADPH OxidasesPoly(ADP-ribose) PolymerasesProtein Kinase CReactive Oxygen SpeciesSignal TransductionFocal Adhesion Kinase 2Hydrogen PeroxideNADPH OxidasesPoly(ADP-ribose) PolymerasesProtein Kinase CReactive Oxygen SpeciesTRPM2 protein, mouseTRPM Cation ChannelsERKmicrogliaNOXOxidative stressPARP-1PKCPYK2TRPM2

Identifiers

PMID40375438
PMCPMC12086945

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.