Evidence map›Paper›PMID 40375536›Full record

ArticleActa dermato-venereologica2025

Inhibitory Effect of 505 nm Green Light Emitting Diode on Melanin Synthesis in Cellular Experiments and a Human Intervention Study.

Yoshihito Mima, Takehiro Yamada, Jun Omatsu, Takashi Yamashita, Shota Suzuki, Takayuki Takechi, Mayumi Ichikawa, Kentaro Yamazaki, Shinichi Sato, Ayumi Yoshizaki

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta dermato-venereologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yoshihito MimaDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Takehiro YamadaDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Jun OmatsuDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Takashi YamashitaDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Shota SuzukiHYOJO Science Lab, Research and Development Department, YA-MAN Ltd, Tokyo, Japan.
Takayuki TakechiHYOJO Science Lab, Research and Development Department, YA-MAN Ltd, Tokyo, Japan.
Mayumi IchikawaHYOJO Science Lab, Research and Development Department, YA-MAN Ltd, Tokyo, Japan.
Kentaro YamazakiHYOJO Science Lab, Research and Development Department, YA-MAN Ltd, Tokyo, Japan.
Shinichi SatoDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Ayumi YoshizakiDepartment of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. ayuyoshi@me.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Light-emitting diodes (LEDs) are currently gaining attention in aesthetic medicine for their applications in the treatment of pigmentation and wrinkles. While several wavelengths of LEDs have been reported to inhibit melanin production by targeting melanin synthesis-related enzymes, melanosomes, and paracrine factors stimulating melanogenesis from keratinocytes, the effects of green LED (GLED) remain largely unexplored. This study aimed to investigate the effects of GLED on cell viability, melanin production, and melanin-related gene expression using B16 melanoma cells and 3-dimensional (3D) skin models. Furthermore, its efficacy in improving skin pigmentation was evaluated through a human intervention study with GLED-equipped facial masks. The melanin synthesis inhibitory effects of 505 nm GLED were evaluated using B16 mouse melanoma cells, a 3D skin model containing melanocytes, and a human intervention study with 505 nm GLED-equipped masks. 505 nm GLED irradiation reduced melanin production in melanogenesis-induced B16 mouse melanoma cells by suppressing the gene expression levels of microphthalmia-associated transcription factor and tyrosinase. Furthermore, GLED irradiation also reduced melanin content in 3D skin models without affecting cell viability. Finally, a human intervention study demonstrated that GLED irradiation on human facial skin effectively decrease pigmentation. These findings suggest 505 nm GLED is a potential depigmentation strategy.

Indexed as

MelaninsMelanocytesSkinSkin PigmentationAdultAnimalsCell Line, TumorCell SurvivalFemaleGreen LightHumansMaleMelanoma, ExperimentalMiceMicrophthalmia-Associated Transcription FactorMonophenol MonooxygenaseMelaninsMicrophthalmia-Associated Transcription FactorMITF protein, humanMitf protein, mouseMonophenol Monooxygenase

Identifiers

PMID40375536
PMCPMC12105538

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.