Evidence map›Paper›PMID 40375989›Full record

ReviewFrontiers in immunology2025

Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review.

Mohamed T El-Saadony, Ahmed M Saad, Dina Mostafa Mohammed, Sameh A Korma, Mohammad Y Alshahrani, Ahmed Ezzat Ahmed, Essam H Ibrahim, Heba M Salem, Samar Sami Alkafaas, Abdullah M Saif and 10 more

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Plants (Basel, Switzerland) · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Sea Buckthorn (Foods (Basel, Switzerland) · 2026
    Review
  17. Superior efficacy of 2%Open veterinary journal · 2026
    Article
  18. Article
  19. Article
  20. Bioactive Potential and COX-2 Interaction ofMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mohamed T El-SaadonyDepartment of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Ahmed M SaadBiochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Dina Mostafa MohammedNutrition and Food Sciences Department, National Research Centre, Giza, Egypt.
Sameh A KormaDepartment of Food Science, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Mohammad Y AlshahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Ahmed Ezzat AhmedBiology Department, College of Science, King Khalid University, Abha, Saudi Arabia.
Essam H IbrahimBiology Department, College of Science, King Khalid University, Abha, Saudi Arabia.
Heba M SalemDepartment of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Samar Sami AlkafaasMolecular Cell Biology Unit, Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Abdullah M SaifDivision of Biochemistry, Department of Chemistry, Tanta University, Faculty of Science, Tanta, Egypt.
Sara Samy ElkafasFaculty of Control System and Robotics, Information Technologies, Mechanics and Optics University, Saint-Petersburg, Russia.
Mohamed A FahmyDepartment of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Taia A Abd El-MageedSoils and Water Science Department, Faculty of Agriculture, Fayoum University, Fayoum, Egypt.
Mariam M AbadyNutrition and Food Sciences Department, National Research Centre, Giza, Egypt.
Hanya Y AssalFaculty of Biotechnology, October University for Modern Sciences and Arts, 6th October City, Egypt.
Marawan K El-TarabilyFaculty of Medicine, University of Debrecen, Debrecen, Hungary.
Betty T MathewDepartment of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
Synan F AbuQamarDepartment of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
Khaled A El-TarabilyDepartment of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates.
Salam A IbrahimFood Microbiology and Biotechnology Laboratory, Food and Nutritional Science Program, North Carolina A&T State University, Greensboro, NC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, medicinal plants have gained significant attention in modern medicine due to their accessibility, affordability, widespread acceptance, and safety, making herbal remedies highly valued globally. Consequently, ensuring medicinal plants' quality, efficacy, and safety has become a critical concern for developed and developing nations. The emergence of multidrug-resistant microorganisms poses a serious global health threat, particularly in low-income regions, despite significant advancements in antimicrobial drugs and medical research over the past century. The rapid spread of these multidrug-resistant infections is primarily attributed to improper prescriptions, overuse, and unregulated access to antibiotics. Addressing these challenges, the standardization of plant-derived pharmaceuticals could pave the way for a transformative era in healthcare. Preserving and leveraging the historical knowledge of medicinal plants is essential before such valuable information is lost. Recently, there has been growing interest among natural and pharmaceutical scientists in exploring medicinal plants as potential sources of antimicrobial agents. This current review aims to identify the most common pathogens threatening human health, analyze the factors contributing to the rise of drug-resistant microorganisms, and evaluate the widespread use of medicinal plants across various countries as alternative antibiotics, highlighting their unique mechanisms of antimicrobial resistance.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsDrug Resistance, Multiple, BacterialPhytochemicalsPlants, MedicinalAnimalsHumansPhytotherapyAnti-Bacterial AgentsAnti-Infective AgentsPhytochemicalsantibioticsantimicrobial agentsherbal medicinehuman healthmechanism of actionmultidrug resistancepathogens

Identifiers

PMID40375989
PMCPMC12079674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.