Evidence map›Paper›PMID 40376262›Full record

ArticleInternational journal of drug discovery and pharmacology2024

Unraveling the Roles of HIF-1, HO-1, GLUT-1 and GLUT-4 in Myocardial Protection.

Lionel Chong, Nicholas Dushaj, Ani Rakoubian, Johnathan Yarbro, Satoru Kobayashi, Qiangrong Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of drug discovery and pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lionel ChongDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568-8000, USA.
Nicholas DushajDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568-8000, USA.
Ani RakoubianDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568-8000, USA.
Johnathan YarbroDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568-8000, USA.
Satoru KobayashiDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568-8000, USA.
Qiangrong LiangDepartment of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, NY 11568-8000, USA.

Funding

Necessity of AMPK Activation for Caloric Restriction-Induced CardioprotectionR15HL120027 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI LIANG, QIANGRONG · 2014 to 2014
$432k
Deciphering the role of lysosomal membrane permeabilization in Diabetic Cardiac InjuryR15HL161737 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI KOBAYASHI, SATORU · 2022 to 2022
$428k
Deciphering the Role of AMPK in Doxorubicin CardiotoxicityR15HL163707 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI LIANG, QIANGRONG · 2023 to 2023
$428k
Deciphering the Role of Mitophagy in the Heart during FastingR15HL137130 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI LIANG, QIANGRONG · 2018 to 2018
$427k
NHLBI NIH HHS R15 HL120027NHLBI NIH HHS R15 HL137130NHLBI NIH HHS R15 HL161737NHLBI NIH HHS R15 HL163707
6 · The paper itself

Abstract

Cardiomyocytes are highly dependent on oxygen for optimal function. Disruption of oxygen availability, as in the case of ischemic heart disease, can significantly impair heart function. Moreover, comorbidities like diabetes, hyperlipidemia, and hypertension can exacerbate ischemic cardiac injury. However, cardiomyocytes possess inherent protective mechanisms that can be activated to enhance myocardial survival under such conditions. Understanding the functions and regulatory mechanisms of these cardioprotective genes is crucial for advancing our knowledge of cardiovascular health and for developing therapeutic strategies. This review examines the intricate mechanisms of cardioprotection, with a focus on key genes and proteins, including hypoxia-inducible factor-1 (HIF-1), heme oxygenase-1 (HO-1), glucose transporter 1 (GLUT-1), and GLUT-4. In addition, the review explores the roles and regulation of these factors in the heart under ischemic stress, shedding light on their relevance in conditions like diabetes, hypertension, and hyperlipidemia/atherosclerosis. Moreover, it highlights the complex interplay among their mechanisms and suggests opportunities for developing targeted therapiesfor the treatment of ischemic heart disease, hypertension, and hyperlipidemia.

Indexed as

cardioprotectionGLUT-1GLUT-4HIF-1HO-1

Identifiers

PMID40376262
PMCPMC12080592

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.