Evidence map›Paper›PMID 40376451›Full record

ArticlePolymer chemistry2025

Generation of topologically defined linear and cyclic DNA bottle brush polymers

Nicholas G Pierini, Wynter A Paiva, Owen C Durant, Aubrianna M Dobbins, Ben B Wheeler, Matthew E Currier, James Vesenka, Nathan J Oldenhuis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymer chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas G PieriniDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire 23 Academic Way Parsons Hall Durham NH 03824 USA nathan.oldenhuis@unh.edu.
Wynter A PaivaDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire 23 Academic Way Parsons Hall Durham NH 03824 USA nathan.oldenhuis@unh.edu.
Owen C DurantDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire 23 Academic Way Parsons Hall Durham NH 03824 USA nathan.oldenhuis@unh.edu.
Aubrianna M DobbinsDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire 23 Academic Way Parsons Hall Durham NH 03824 USA nathan.oldenhuis@unh.edu.
Ben B WheelerSchool of Molecular and Physical Sciences, University of New England 11 Hills Beach Road Biddeford ME 04005 USA.
Matthew E CurrierDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire 23 Academic Way Parsons Hall Durham NH 03824 USA nathan.oldenhuis@unh.edu.
James VesenkaSchool of Molecular and Physical Sciences, University of New England 11 Hills Beach Road Biddeford ME 04005 USA.
Nathan J OldenhuisDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire 23 Academic Way Parsons Hall Durham NH 03824 USA nathan.oldenhuis@unh.edu.ORCID https://orcid.org/0000-0003-4256-0826

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8M
Using DNA hydrogels to mimic, exploit, and fundamentally investigate extracellular matricesR35GM154998 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Nathan John Oldenhuis · 2024 to 2026
$1.1M
NIGMS NIH HHS P20 GM113131NIGMS NIH HHS R35 GM154998
6 · The paper itself

Abstract

Herein, we report a graft-to approach for synthesizing linear and circular double-stranded DNA (dsDNA) bottlebrush polymers (BBPs). Using a bioreactor, plasmid DNA (pDNA) serves as an inexpensive and abundant source of circular, biodegradable, and unimolecular polymers. pDNA is easily converted to the linear isoform through enzymatic restriction, providing access to polymeric backbones with distinct topological states. DNA is grafted with polyethylene glycol monomethyl ether chloroethylamines (mPEGCEA) to yield DNA BBPs. Importantly this PEGylation occurs rapidly under ambient conditions in aqueous buffer. By varying the molecular weight of mPEGCEA (

Identifiers

PMID40376451
PMCPMC12070894

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.