ArticleJournal of global health2025
Association of age at menarche and menopause, reproductive lifespan, and stroke among Chinese women: results from a national cohort study.
Article in Journal of global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Insights into the relationship between menopausal timing and risk of cardiovascular disease: a systematic review and meta-analysis of Mendelian randomization analyses.Systematic reviews · 2026Pooled it
- Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The association between age of menarche, age of menopause, reproductive lifespan and risk of stroke in Chinese women remains unclear and requires further clarification. Methods: A stratified multi-stage random sampling method was used to select participants at baseline in 2012-2015. The participants' basic information was collected through a standardised questionnaire by professional investigator and examined by trained medical personnel. Follow-up was conducted in 2018-2020 to collect the stroke events. The Cox proportional hazards models were used to evaluate hazard ratios between reproductive factors and stroke risk. Results: Overall, 11 256 women (5155 non-menopausal women and 6101 menopausal women) were included (mean (x̄); standard deviation (SD) age = 55.2; 12.9 years). The risk was highest in women with menarche at age ≥17 years (hazard ratio (HR) = 1.290; 95% confidence interval (CI) = 0.959-1.733) and with reproductive lifespan ≤28 years (HR = 1.643; 95% CI = 1.041-2.595). Age at menarche was positively associated with risk of stroke (HR = 1.086; 95% CI = 1.006-1.172). There was a negative association between age at menopause and stroke risk in women with two live births (HR = 0.897; 95% CI = 0.834-0.964). Reproductive lifespan was negatively associated with risk of stroke (HR = 0.963; 95% CI = 0.946-1.027). Subgroup analysis also showed that association between age at menarche, reproductive lifespan and stroke events. Conclusions: Chinese women with late age at menarche and shorter reproductive lifespan have higher risk of stroke according to a large prospective study.
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