Evidence map›Paper›PMID 40377059›Full record

ReviewRNA biology2025

Translation elongation: measurements and applications.

Leslie Watkins, Mulin Li, Bin Wu

Abstract readReview
In one paragraph

Review in RNA biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. NNature · 2026
    Article
  2. RiboScreenBiomedicines · 2026
    Review
  3. Review
  4. Translational Fidelity Decline in the Aging Oocyte and Embryo Development.International journal of molecular sciences · 2026
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leslie WatkinsDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7163-2588
Mulin LiDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1296-8268
Bin WuDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9442-3041

Funding

Biochemistry, Cellular and Molecular Biology Program: JHU BioGREAT (Biomedical Graduate REsiliency & Adaptability Training)T32GM144272 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Takanari Inoue · 2022 to 2026
$5.4M
Developing optogenetic and chemogenetic approaches to control RNA metabolism in live cellsR01GM136897 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WU, BIN · 2021 to 2024
$1.8M
NIGMS NIH HHS R01 GM136897NIGMS NIH HHS T32 GM144272
6 · The paper itself

Abstract

Translation converts genetic information in mRNAs into functional proteins. This process occurs in four major steps: initiation, elongation, termination and ribosome recycling; each of which profoundly impacts mRNA stability and protein yield. Over recent decades, regulatory mechanisms governing these aspects of translation have been identified. In this review, we focus on the elongation phase, reviewing the experimental methods used to measure elongation rates and discussing how the measurements shed light on the factors that regulate elongation and ultimately gene expression.

Indexed as

Peptide Chain Elongation, TranslationalProtein BiosynthesisRNA, MessengerAnimalsHumansRibosomesRNA StabilityRNA, Messengercodon optimalityribosomeribosome profilingRNA modificationsingle moleculeTranslation elongation

Identifiers

PMID40377059
PMCPMC12087489

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.