Evidence map›Paper›PMID 40377337›Full record

ArticleMicrobiology spectrum2025

Gut commensal bacteria influence colorectal cancer development by modulating immune response in AOM/DSS-treated mice.

Danlei Zhou, Yujing Sun, Peipei Ding, Xiaochao Wang, Ling Li, Luying Li, Xinyue Lv, Tian Liao, Jianfeng Chen, Wei Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Danlei ZhouInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0003-0616-8712
Yujing SunInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Peipei DingInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Xiaochao WangInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Ling LiInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Luying LiInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Xinyue LvInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Tian LiaoDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China.
Jianfeng ChenInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Wei ZhangInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Qi WangInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Qing-Hai JiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, Shanghai, China.
Feng GaoDepartment of Neuroimmunology, Zhengzhou University, Zhengzhou, Henan, China.
Weiguo HuInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0002-7397-6800

Funding

Major State Basic Research Development Program of China 2013CB910802National Natural Science Foundation of China 81790254National Natural Science Foundation of China 81872354National Natural Science Foundation of China 82121004National Natural Science Foundation of China 91629301
6 · The paper itself

Abstract

The gut microbiota has been closely associated with the pathogenesis of colorectal cancer (CRC). However, precise identification of particular microorganisms promoting CRC carcinogenesis, and more importantly those blocking tumor development, has been challenging based on human gut microbiota profiling studies. With a well-established azoxymethane/dextran sodium sulfate induction murine CRC model, we found a subset of mice consistently failed to develop CRC. This genetically homogeneous but cancer-refractory population gave us a unique opportunity to reveal that the microbial compositions between mice with and without CRC formation are indeed distinct, indicating key different gut microbiota between those groups are responsible for the differential susceptibility of the animals to CRC development. Our analysis revealed that

Indexed as

BacteriaColorectal NeoplasmsGastrointestinal MicrobiomeAnimalsAzoxymethaneDextran SulfateDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLNF-kappa BAzoxymethaneDextran SulfateNF-kappa BAOM/DSScolorectal cancerEubacterium dolichummicrobiotaNF-κB

Identifiers

PMID40377337
PMCPMC12211034

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.