Evidence map›Paper›PMID 40377774›Full record

ArticleActa parasitologica2025

Oral Treatment of Lactoferrin Nanocapsules Modulates the Immune Response of Mice to a Cryptosporidiosis Infection.

Ibrahim Aly, Waleed E Elawamy, Hanan T Hamza, Hany M El-Wahsh, Ahmed El-Bahiry, Amira Matter, Lamia I Bakr

Abstract read
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In one paragraph

Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ibrahim AlyParasitology Department, Theodor Bilharz Research Institute, Cairo, Egypt.
Waleed E ElawamyDepartment of Pathology (Microbiology Unit), College of Medicine, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Hanan T HamzaBiology Department, College of Science, Jouf University, 2014, Sakaka, Saudi Arabia.
Hany M El-WahshMarine Biology Department, Faculty of Marine 555, King Abdulaziz University, Jeddah, Saudi Arabia.
Ahmed El-BahiryParasitology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Amira MatterZoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Lamia I BakrZoology Department, Faculty of Science, Tanta University, Tanta, Egypt. bakrlamiaa73@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe current study was to evaluate the immunomodulatory impact of either lactoferrin (LF), lactoferrin nanocapsule (LF-NC), or lactoferrin conjugation with nanazoxid (NZ). Moreover, identifying drugs can effectively eliminate and successfully treat the infection with Cryptosporidium.

methodsSixty male Swiss albino mice were divided into six groups, each of 10 mice. G1 served as the control, and G2 was inoculated with 10

resultsThe cytokines TGF-β, INF-γ, and IL-10 were increased during infection and decreased following therapy. Mutually, the quantity of pathological lesions and oocysts in the ileal tissues was significantly diminished with the NZ plus LF-NC treatment. In addition, a considerable reduction of both fecal and intestinal samples, as well as a notable deterioration in oocyst counts, suggested that treatment with NZ alone or in combination with LF-NC was more effective.

conclusionLF or LF-NC was found to exert a potent immunomodulatory effect on infected mice as well as minimize pathological lesions. This therapy approaches a successful therapeutic alternative for the treatment of cryptosporidiosis with few adverse effects.

Indexed as

CryptosporidiosisLactoferrinNanocapsulesAdministration, OralAnimalsCytokinesDisease Models, AnimalFecesMaleMiceNitro CompoundsThiazolesCytokinesLactoferrinNanocapsulesnitazoxanideNitro CompoundsThiazolesCryptosporidiosisCytokinesDrug therapyHistopathological lesionsLactoferrin nanocapsuleNanazoxid

Identifiers

PMID40377774
PMCPMC12084178

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.