Evidence map›Paper›PMID 40377898›Full record

ArticleJournal of neuro-oncology2025

Long-term neurocognitive sequelae in pediatric medulloblastoma survivors treated according to the HIT protocol.

Iuliia A Aldeeva, Elena V Glebova, Roza A Sarkisyan, Elizaveta N Romanova, Nadezhda M Karpova, Valeriia G Shapovalova, Alexander F Karelin

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In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iuliia A AldeevaRUDN University, Moscow, Russia. yu.aldeeva@mail.ru.ORCID http://orcid.org/0009-0005-3133-3283
Elena V GlebovaRUDN University, Moscow, Russia.ORCID https://orcid.org/0000-0003-3553-1234
Roza A SarkisyanRUDN University, Moscow, Russia.ORCID https://orcid.org/0000-0002-9142-5375
Elizaveta N RomanovaRUDN University, Moscow, Russia.ORCID https://orcid.org/0000-0002-8568-0118
Nadezhda M KarpovaRUDN University, Moscow, Russia.ORCID https://orcid.org/0000-0002-4546-6926
Valeriia G ShapovalovaRUDN University, Moscow, Russia.ORCID https://orcid.org/0009-0005-0966-6452
Alexander F KarelinDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia, Moscow, Russia.ORCID https://orcid.org/0000-0001-6383-2822

Funding

RUDN University 212202-2-000
6 · The paper itself

Abstract

objectiveMedulloblastoma is the most prevalent malignant brain tumour in children. Although contemporary comprehensive anticancer therapy has been shown to result in favourable survival and relapse outcomes, the long-term toxic effects on cognitive and motor function remain a concern. This study aims to investigate the long-term neurotoxic effects on cognitive function in paediatric medulloblastoma survivors.

methodData from 70 patients (M

resultsGLM revealed that remission > 4 years was associated with poorer processing speed, attention, and executive functions: cognitive flexibility, inhibitory control, planning, and working memory compared to participants with shorter remission. Induction therapy with methotrexate had more pronounced long-term negative effects on processing speed. However, no significant effects were observed across different radiation doses.

conclusionsRemission duration emerged as a more significant predictor of a poor neurocognitive outcome than chemotherapy type or radiation dose, that is, the longer the remission, the more pronounced the neurocognitive impairment becomes. This highlights the need for continued monitoring and the development of targeted rehabilitation interventions for paediatric medulloblastoma survivors.

Indexed as

Cancer SurvivorsCerebellar NeoplasmsMedulloblastomaAdolescentChildFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsHITLong-term effectsMedulloblastomaNeurotoxicityPediatric brain tumour survivors

Identifiers

PMID40377898

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.