Evidence map›Paper›PMID 40377914›Full record

ArticleJournal of medicinal chemistry2025

Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1.

Tina Schermeng, Alexander Fürll, Fabian Liessmann, Lukas von Bredow, Jan Stichel, C David Weaver, Maik Tretbar, Jens Meiler, Annette G Beck-Sickinger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tina SchermengInstitute of Biochemistry, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0001-7508-3574
Alexander FürllInstitute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0008-3141-2434
Fabian LiessmannInstitute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.ORCID 0009-0007-9199-1629
Lukas von BredowInstitute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.
Jan StichelInstitute of Biochemistry, Leipzig University, Leipzig 04103, Germany.
C David WeaverDepartment of Chemistry, Department of Pharmacology and Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Maik TretbarInstitute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0003-3819-7358
Jens MeilerInstitute for Drug Discovery, Leipzig University, Leipzig 04103, Germany.
Annette G Beck-SickingerInstitute of Biochemistry, Leipzig University, Leipzig 04103, Germany.ORCID 0000-0003-4560-8020

Funding

Structural Determinants of Allosteric Modulation of Brain GPCRsR01DA046138 · NIDA · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2019 to 2023
$2.0M
Personalized Structural Biology: Enabling Exome Interpretation in Undiagnosed DiseasesR01LM013434 · NLM · VANDERBILT UNIVERSITY · PI CAPRA, JOHN ANTHONY, MEILER, JENS · 2021 to 2024
$1.4M
GPU-Accelerated Parallel Computer for Life Sciences ResearchS10OD032234 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2022 to 2022
$600k
Parallel Computer with High Memory NodesS10OD016216 · OD · VANDERBILT UNIVERSITY · PI PISTON, DAVID W · 2013 to 2013
$598k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NIDA NIH HHS R01 DA046138NIH HHS S10 OD016216NIH HHS S10 OD020154NIH HHS S10 OD032234NLM NIH HHS R01 LM013434
6 · The paper itself

Abstract

Several studies have linked chemerin/chemokine-like receptor 1 (CMKLR1) to inflammation, leukocyte recruitment, and obesity. Reduced cellular activation may reduce inflammation in adipose tissues. High-throughput screening identified a novel antagonist (VU0514009), which was optimized to compound

Indexed as

Receptors, ChemokineReceptors, G-Protein-CoupledAnimalsBinding SitesChemokinesHEK293 CellsHumansMolecular Docking SimulationStructure-Activity RelationshipChemokinesCMKLR1 protein, humanGPR1 protein, humanReceptors, ChemokineReceptors, G-Protein-Coupled

Identifiers

PMID40377914
PMCPMC12169613

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.