ArticleScientific reports2025
The causal effects of systemic antioxidant capacity on male infertility: A two-sample mendelian randomization analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The present research aimed to assess the potential causal relationship between systemic antioxidant capacity and male infertility using a two-sample Mendelian randomization approach. The primary MR analysis utilized the inverse variance weighted (IVW)method, supplemented by complementary analyses including MR-Egger, weighted mode, simple mode, and weighted median methods. For male infertility, the available summarized data were gained from the open database (IEU OPEN GWAS PROJECT), which includes a total of 680 male patients with infertility and 72,799 controls of European population.10 biomarkers related to systemic antioxidant capacity were examined to investigate their potential association with male infertility, including glutathione S-transferase (GST), superoxide dismutase(SOD), glutathione peroxidase(GPX), catalase (CAT), total bilirubin, albumin, α-tocopherol, ascorbate, retinol, and uric acid. MR analyses using IVW mode revealed that genetically determined systemic antioxidant capacity biomarkers had no causal effects on male infertility risk, including GST(OR = 1.08, 95%CI: 0.91-1.29, P = 0.35), SOD(OR = 0.83, 95%CI: 0.66-1.04, P = 0.11), GPX(OR = 1.12, 95%CI: 0.92-1.36,P = 0.26), CAT(OR = 1.04, 95%CI: 0.83-1.29, P = 0.75), total bilirubin(OR = 0.98, 95%CI: 0.94-1.01, P = 0.18), albumin(OR = 1.14, 95%CI: 0.73-1.76, P = 0.57), α-tocopherol(OR = 0.56, 95%CI: 0.03-9.38, P = 0.69), ascorbate(OR = 1.06, 95%CI: 0.24-4.60, P = 0.94), retinol(OR = 1.29, 95%CI: 0.34-4.96, P = 0.71), and uric acid (OR = 0.88, 95% CI : 0.67-1.17, P = 0.39). The current study found no significantly causal link between systemic antioxidant capacity and male infertility. Further research with larger sample sizes and data from different ethnicities is needed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.