Evidence map›Paper›PMID 40379944›Full record

SynthesisScientific reports2025

The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study.

Qifan Zheng, Tong Xu, Shiyin Luo, Jiahui Zhao, Yue Ying, Nan Liu, Aijia Jiang, Yaping Pan, Dongmei Zhang

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qifan ZhengDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Tong XuDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Shiyin LuoDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Jiahui ZhaoDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Yue YingDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Nan LiuDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Aijia JiangDepartment of Oral Mucosiology, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Yaping PanDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China.
Dongmei ZhangDepartment of Periodontics, Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology, China Medical University, Heping District, Nanjing North Street No. 117, Shenyang, 110002, China. zhangdongmei@cmu.edu.cn.

Funding

National Natural Science Foundation of China 81970943
6 · The paper itself

Abstract

To investigate the causal relationship between oral infectious diseases and lacunar stroke (LS) and to identify the role of interleukin-1α (IL-1α), interleukin-6 (IL-6), tumor necrosis factor (TNF), and C-reaction protein (CRP) as potential mediators. The meta-analysis incorporating cross-sectional studies was carried out. Additionally, two-sample Mendelian randomization (MR) analysis was performed to explore the associations between genetically predicted oral infectious diseases (including dental caries, periodontitis, and pulp and periapical diseases) and lacunar stroke, utilizing summary-level data from genome-wide association studies (GWAS). This was followed by a mediation analysis to explore the role of IL-1α, IL-6, TNF, and CRP. Meta-analysis suggested that individuals with periodontitis have a 5.16 times higher risk of developing LS compared to those without periodontitis (95%CI 3.68-7.24). Genetically predicted pulp and periapical diseases (Odds ratios [OR]: 1.20, 95% CI 1.03-1.41) and periodontitis (OR: 1.24, 95%CI 1.03-1.49) showed a moderate association with LS. However, the mediation analysis yielded negative results. The evidence derived from both the MR study and the meta-analysis suggested a potential association between periodontitis and LS. These findings indicated that periodontitis might play a role in the development of LS. However, given the limitations inherent in our research, further studies are necessary to validate these conclusions.

Indexed as

PeriodontitisStroke, LacunarC-Reactive ProteinCross-Sectional StudiesDental CariesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterleukin-1alphaInterleukin-6Mendelian Randomization AnalysisPolymorphism, Single NucleotideRisk FactorsTumor Necrosis Factor-alphaC-Reactive ProteinInterleukin-1alphaInterleukin-6Tumor Necrosis Factor-alphaLacunar strokeMendelian randomization analysisMeta-analysisOral infectious diseasesPeriodontitis

Identifiers

PMID40379944
PMCPMC12084548

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.