Evidence map›Paper›PMID 40379984›Full record

ReviewPediatric nephrology (Berlin, Germany)2025

The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit.

Aadil Kakajiwala, Nivedita Kamath, Saudamini Nesargi, Lisa Goto, Suma Bhat Hoffman, Brianna Michelle Liberio, Jennifer A Rumpel, Mona Khattab, Arwa Nada, Christine Stoops and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aadil KakajiwalaDivision of Pediatric Critical Care Medicine, Children's National Hospital, 111 Michigan Ave NW, Washington, DC, 20010, USA. akakajiwal@childrensnational.org.ORCID http://orcid.org/0000-0002-4172-916X
Nivedita KamathDepartment of Pediatric Nephrology, St. John's Medical College Hospital, Bangalore, India.
Saudamini NesargiDepartment of Neonatology, St. John's Medical College Hospital, Bangalore, India.
Lisa GotoDivision of Pediatric Critical Care Medicine, Children's National Hospital, 111 Michigan Ave NW, Washington, DC, 20010, USA.
Suma Bhat HoffmanDivision of Neonatology, Children's National Hospital, Washington, DC, USA.
Brianna Michelle LiberioDivision of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Jennifer A RumpelDivision of Neonatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mona KhattabDivision of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Arwa NadaDivision of Pediatric Nephrology, Loma Linda University Children's Hospital, Loma Linda University, Loma Linda, CA, USA.
Christine StoopsDivision of Neonatology, University of Alabama at Birmingham and Children's of Alabama, Birmingham, AL, USA.
Sofia I PerazzoDivision of Neonatology, Children's National Hospital, Washington, DC, USA.
Matthew W HarerDivision of Neonatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared spectroscopy (NIRS) is a relatively recent technology, first applied in clinical contexts in the early 1970s. Critically ill neonates in the intensive care unit face unique post-natal adaptations that can be challenging when compounded by clinical co-morbidities. Given the size and limited blood volume of these patients, there is a need for non-invasive monitoring methods that go beyond traditional vital signs and laboratory assessments. NIRS offers a potential approach for monitoring regional tissue oxygenation and perfusion of the kidney with a potential for early detection of acute kidney injury in high-risk neonates. However, its application is not without challenges, including inconsistent normative values, technological and technique-related limitations, and uncertainties about its clinical applicability. Despite these challenges, NIRS monitoring of kidney oxygenation shows promise for supporting kidney health and informing clinical care decisions. In this educational review, we aim to outline the basic principles of NIRS as it relates to kidney oxygenation, summarize the current literature on its use for monitoring and clinical decision-making, discuss its limitations and knowledge gaps, and propose investigative approaches with future research directions.

Indexed as

Acute Kidney InjuryKidneyOxygenCritical IllnessHumansInfant, NewbornIntensive Care Units, NeonatalMonitoring, PhysiologicSpectroscopy, Near-InfraredOxygenKidney regional oxygenationNear-infrared spectroscopyNeonatal acute kidney injuryTissue oxygen extraction

Identifiers

PMID40379984

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.