ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025
ASBT governs neonatal bile acid homeostasis early in life despite its strong ileal repression.
Joyce Morales Aparicio, Zhengzheng Hu, Amy M Peiper, Lufuno Phophi, Haley M Wilt, Meera S Nair, Harrison B Winton, Katherine Blessing, Gabriela P Romero-Gonzalez, Stephanie M Karst
Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
10 authors.
Joyce Morales AparicioDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Zhengzheng HuDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Amy M PeiperDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-9291-5563
Lufuno PhophiDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Haley M WiltDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-6983-2700
Meera S NairDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Harrison B WintonDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Katherine BlessingDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Gabriela P Romero-GonzalezDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.
Stephanie M KarstDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-0406-4637
Funding
BASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3M
Elucidation of Pathogenic Mechanisms underlying Norovirus DiarrheaR01AI162970 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2021 to 2025
$3.0M
Regulation of enteric norovirus infection by host-derived and microbiota-transformed bile acidsR56AI141478 · NIAID · UNIVERSITY OF FLORIDA · PI KARST, STEPHANIE M · 2024 to 2024
$643k
The Role of Norovirus Interactions with the Epithelial Barrier in Acute GastroenteritisF30AI172364 · NIAID · UNIVERSITY OF FLORIDA · PI Amy Marie Peiper · 2023 to 2026
$144k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F30AI172364HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI162970HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R56AI141478HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007110NIAID NIH HHS F30 AI172364NIAID NIH HHS R01 AI162970NIAID NIH HHS R56 AI141478NIAID NIH HHS T32 AI007110
6 · The paper itself
Abstract
Neonatal bile acid metabolism is distinct from that of adults due to developmental regulation of key transporters and enzymes. The apical sodium-dependent bile acid transporter (ASBT) is transiently repressed in the intestine after birth, yet its role in neonatal bile acid homeostasis remains unclear. Here, we demonstrate that ASBT plays a crucial role in limiting fecal bile acid loss and suppressing hepatic bile acid synthesis in neonates. ASBT-deficient pups exhibited a marked decrease in serum bile acids and concomitant increase in fecal bile acids, accompanied by upregulated hepatic bile acid synthesis genes, including CYP7A1, CYP7B1, and CYP27A1. We also illuminated a tissue-specific distinction in neonatal negative feedback regulation of bile acid synthesis, with intact hepatic regulation but impaired intestinal regulation. Our study identifies ASBT as a key regulator of neonatal bile acid homeostasis despite its strong repression early in life, highlighting its role in bile acid retention and synthesis regulation.
Indexed as
Bile Acids and SaltsHomeostasisIleumLiverOrganic Anion Transporters, Sodium-DependentSymportersAnimalsAnimals, NewbornFecesMaleMiceMice, Inbred C57BLMice, KnockoutBile Acids and SaltsOrganic Anion Transporters, Sodium-Dependentsodium-bile acid cotransporterSymportersASBTFXRneonatal bile acid metabolism
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
ASBT governs neonatal bile acid homeostasis early in life despite its strong ileal repression. · full record | Socratic