Evidence map›Paper›PMID 40380190›Full record

ArticleJournal of nanobiotechnology2025

Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer.

Dong Zhong, Xiaoxin Yang, Jinhui Yang, Zhisheng Luo, Zhichao Feng, Mengtian Ma, Yunjie Liao, Yongxiang Tang, Yu Wen, Jun Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. MOF-Derived Semiconductor Materials for Wastewater-Driven Energy Production and Environmental Remediation.Water environment research : a research publication of the Water Environment Federation · 2026
    Review
  3. Article
  4. Article
  5. The role of NADFrontiers in oncology · 2026
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dong ZhongDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Xiaoxin YangDepartment of Radiology, Second Xiangya Hospital of Central South University, 139 Renming Middle Road Changsha, Changsha, Hunan, China. yxxawy@163.com.
Jinhui YangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Zhisheng LuoDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Zhichao FengSJTU-Ruijin-UIH Institute for Medical Imaging Technology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengtian MaDepartment of Radiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Yunjie LiaoDepartment of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yongxiang TangDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Yu WenFurong Laboratory, Central South University, Changsha, Hunan, 410008, China.
Jun LiuDepartment of Radiology, Second Xiangya Hospital of Central South University, 139 Renming Middle Road Changsha, Changsha, Hunan, China. junliu123@csu.edu.cn.
Shuo HuDepartment of Nuclear Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China. hushuo2018@163.com.

Funding

China Postdoctoral Science Foundation 2024M753675Clinical Research Center for Medical Imaging in Hunan Province 2020SK400Key Program of Ministry of Industry and Information Technology of China CEIEC-2022-ZM02-0219Postdoctoral Fellowship Program of CPSF GZC20233197Science and Technology Innovation Program of Hunan Province 2021RC4016Science and Technology Innovation Program of Hunan Province 2021RC4056the National Natural Science Foundation of China 82272045the National Natural Science Foundation of China U22A20303
6 · The paper itself

Abstract

In colorectal cancer treatment, chemotherapeutic agents induce reactive oxygen species (ROS) production, which promotes NAD

Indexed as

Antineoplastic AgentsColorectal NeoplasmsDrug Resistance, NeoplasmOxaliplatinOxygenAnimalsCell Line, TumorElectron TransportGlutathione S-Transferase piHumansMiceNADReactive Oxygen SpeciesTumor MicroenvironmentAntineoplastic AgentsGlutathione S-Transferase piNADOxaliplatinOxygenReactive Oxygen SpeciesBimetallic nanozymesETC disruptionMulti-enzyme activityNAD+ depletionOxaliplatin resistance

Identifiers

PMID40380190
PMCPMC12082870

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.