Evidence map›Paper›PMID 40381168›Full record

ArticleMolecular neurobiology2025

Cold-Induced RNA-Binding Protein (CIRP) Affects Cerebral Ischemia-Reperfusion Injury Through NF-κB Pathway.

Yong Fan, Jingjing Wei, Lili Lin, Jinying Lin, Xiaohua Li, Liyu Xu, Xiaohui Zhou, Yongkun Li, Yongkai Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Role of astrocytes in the pathogenesis of perinatal brain injury.Molecular medicine (Cambridge, Mass.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yong Fan *Central Laboratory, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, Fujian, China.
Jingjing Wei *School of Life Sciences, Fudan University, Shanghai, 200438, China.
Lili LinCollege of Life Sciences, Fujian Normal University, Fuzhou, 350117, Fujian, China.
Jinying LinCentral Laboratory, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, Fujian, China.
Xiaohua LiDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, Fujian, China.
Liyu XuDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, Fujian, China.
Xiaohui ZhouDepartment of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, Fujian, China.
Yongkun LiDepartment of Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, Fujian, China. liyongkun721@139.com.
Yongkai YangDepartment of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, Fujian, China. yang0121kai@126.com.

Funding

Clinical Specialty Discipline Cultivation and Strengthening Project of Fuzhou City 20220201Health Research Innovation Team Cultivation Project of Fuzhou City 2021-S-wt1Joint Fund for Science and Technology Innovation of Fujian No.2023Y9288Key Clinical Specialty Discipline Construction Project of Fujian Province 20220102Natural Science Foundation of Fujian Province 2022J011304Scientific And Technological Projects of Fuzhou City 2022-S-061The project of Fuzhou first Hospital 2022-YJ-14
6 · The paper itself

Abstract

The pathological and physiological mechanisms for effectively mitigating ischemia-reperfusion (I/R) injury and preserving brain structure and function remain unclear. This study investigates the regulatory mechanism underlying cold-induced RNA-binding protein (CIRP)-mediated NF-κB pathway in cerebral I/R injury and neuronal inflammatory injury. The infarct volume of I/R CIRP

Indexed as

Brain IschemiaNF-kappa BReperfusion InjuryRNA-Binding ProteinsSignal TransductionAnimalsApoptosisCell LineMaleMiceMice, Inbred C57BLMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinCirbp protein, mouseNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinRNA-Binding ProteinsCIRPMCAO/RNF-κB/NLRP3 pathwayPolarization of microglia

Identifiers

PMID40381168

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.