Evidence map›Paper›PMID 40381613›Full record

ArticleNeuron2025

Activity-dependent development of the body's touch receptors.

Celine Santiago, Julianna Siegrist, Nusrat Africawala, Annie Handler, Aniqa Tasnim, Rabia Anjum, Josef Turecek, Brendan P Lehnert, Sophia Renauld, Jinheon Choi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Celine SantiagoDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Julianna SiegristDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Nusrat AfricawalaDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Annie HandlerDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Aniqa TasnimDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Rabia AnjumDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.
Josef TurecekDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Brendan P LehnertDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Sophia RenauldDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Jinheon ChoiDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Michael Nolan-TamarizDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Michael IskolsDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Alexandra R MageeDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Suzanne ParadisDepartment of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02453, USA.
Nikhil SharmaDepartment of Biochemistry and Molecular Biophysics and Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA.
David D GintyDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: david_ginty@hms.harvard.edu.

Funding

Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS097344 · NINDS · HARVARD MEDICAL SCHOOL · PI GINTY, DAVID D · 2016 to 2023
$6.8M
Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate PainR01AT011447 · NCCIH · HARVARD MEDICAL SCHOOL · PI DRUGOWITSCH, JAN, GINTY, DAVID D · 2020 to 2024
$5.3M
The cellular and molecular mechanisms underlying nociception and painDP2NS127278 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHARMA, NIKHIL · 2021 to 2024
$2.4M
Elucidating Cutaneous Mechanosensory Circuits, from Development to DiseaseR35NS132196 · NINDS · HARVARD MEDICAL SCHOOL · PI David D GINTY · 2024 to 2026
$1.8M
Peripheral Activity-Dependent and Molecular Mechanisms that Control Somatosensory System DevelopmentK99NS124993 · NINDS · HARVARD MEDICAL SCHOOL · PI SANTIAGO, CELINE · 2022 to 2023
$200k
NCCIH NIH HHS R01 AT011447NINDS NIH HHS DP2 NS127278NINDS NIH HHS K99 NS124993NINDS NIH HHS R35 NS097344NINDS NIH HHS R35 NS132196
6 · The paper itself

Abstract

We report a role for activity in the development of the primary sensory neurons that detect touch. Genetic deletion of Piezo2, the principal mechanosensitive ion channel in somatosensory neurons, caused profound changes in the formation of mechanosensory end-organ structures. Peripheral-nervous-system-specific deletion of the voltage-gated sodium channel Na

Indexed as

Ion ChannelsMechanoreceptorsSensory Receptor CellsTouchAnimalsMechanotransduction, CellularMiceNAV1.6 Voltage-Gated Sodium ChannelIon ChannelsNAV1.6 Voltage-Gated Sodium ChannelPiezo2 protein, mouseactivity-dependent developmentmechanotransductionPiezo2somatosensory system

Identifiers

PMID40381613
PMCPMC12140874

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.