Evidence map›Paper›PMID 40382530›Full record

ArticleMolecular neurobiology2025

High-Fat Diet-Induced Excessive Accumulation of Cerebral Cholesterol Esters and Microglial Dysfunction Exacerbate Alzheimer's Disease Pathology in APP

Shuhan Yang, Hirofumi Miyazaki, Tunyanat Wannakul, Eiko Amo, Takaomi Saido, Takashi Saito, Hiroki Sasaguri, Motoko Maekawa, Yuji Owada

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuhan Yang *Department of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan.ORCID http://orcid.org/0009-0009-8804-5337
Hirofumi Miyazaki *Department of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan. hirofumi.miyazaki.d6@tohoku.ac.jp.ORCID http://orcid.org/0000-0003-2695-7479
Tunyanat WannakulDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan.ORCID http://orcid.org/0009-0006-3335-9759
Eiko AmoDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan.
Takaomi SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0003-1970-6903
Takashi SaitoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0002-9659-9251
Hiroki SasaguriLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0003-2550-9156
Motoko MaekawaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan.ORCID http://orcid.org/0000-0002-0816-5550
Yuji OwadaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan. yuji.owada.e2@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-5109-0531

Funding

Japan Society for the Promotion of Science 22K11822Japan Society for the Promotion of Science 24KJ0437
6 · The paper itself

Abstract

Epidemiological studies have identified high-fat diet (HFD)-induced obesity as a risk factor for Alzheimer's disease (AD), yet the underlying molecular mechanisms remain inadequately elucidated. Microglia, the brain's innate immune cells, are pivotal in AD brain by engulfing β-amyloid (Aβ) peptides and compacting poorly consolidated Aβ plaques. Microglia are highly susceptible to the metabolic milieu; however, it is unclear how long-term HFD alters the lipid environment and influences microglial phenotype in AD brains. In this study, APP

Indexed as

Alzheimer DiseaseAmyloid beta-Protein PrecursorCerebral CortexCholesterol EstersDiet, High-FatMicrogliaAmyloid beta-PeptidesAnimalsDisease Models, AnimalLipid DropletsMaleMiceMice, Inbred C57BLMice, TransgenicPhagocytosisPlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCholesterol EstersAlzheimer’s diseaseHigh-fat dietLipid dropletLipid metabolismMicroglial function

Identifiers

PMID40382530
PMCPMC12367945

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.