Evidence map›Paper›PMID 40383956›Full record

ArticleEndocrinology and metabolism (Seoul, Korea)2025

Causal Associations of Cardiovascular Proteins and Diabetic Nephropathy Revealed by Mediation and Phenome-Wide Mendelian Randomization.

Lei Chen, Yongdi Zuo, Manrong He, Jingxue Du, Wanxin Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology and metabolism (Seoul, Korea), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lei ChenDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Yongdi ZuoDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Manrong HeDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Jingxue DuDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Wanxin TangDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.

Funding

Chengdu Science and Technology Bureau 2019-YF09-00090-SNScience and Technology Department of Sichuan Province 2024YFFK0388
6 · The paper itself

Abstract

Cardiovascular factors play a critical role in the progression of diabetic nephropathy (DN). This study utilized Mendelian randomization analysis to explore the causal relationships among cardiovascular proteins, risk factors, and DN. Using cis-protein quantitative trait loci (cis-pQTL) data for 90 cardiovascular proteins, we identified C-X3-C motif chemokine ligand 1 (CX3CL1) and colony-stimulating factor-1 (CSF-1) as potential therapeutic targets for DN. CX3CL1 was found to increase DN risk through mechanisms involving body mass index, fasting insulin, and hypertension. Conversely, CSF-1 appeared to protect against DN by reducing the number of monocytes expressing high levels of human leukocyte antigen. Additionally, targeting CX3CL1 could lower the risk of DN as well as other conditions, including acute renal injury, pituitary disorders, and necrotizing vasculopathies. These results highlight CX3CL1 and CSF-1 as promising novel therapeutic targets for DN.

Indexed as

Cardiovascular DiseasesChemokine CX3CL1Diabetic NephropathiesHumansMendelian Randomization AnalysisPhenotypeQuantitative Trait LociRisk FactorsChemokine CX3CL1CX3CL1 protein, humanCardiovascularDiabetic nephropathiesDrug targetInflammatoryMendelian randomization

Identifiers

PMID40383956
PMCPMC12602005

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.