Evidence mapPaperPMID 40384187Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2025

Forging a New Frontier: Antimicrobial Peptides and Nanotechnology Converging to Conquer Gastrointestinal Pathogens.

Christian Shleider Carnero Canales, Cesar Augusto Roque-Borda, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Uner Josseph Pinto Apaza, Vanderson de Jesus Silva, Laura Maria Duran Gleriani Primo, Maura Jennifer Martínez-Morales, Rafael Miguel Sábio, Hélder A Santos and 1 more

Abstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. EradicatingBioactive materials · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. [Fe(phen)ACS omega · 2025
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christian Shleider Carnero CanalesVicerrectorado de Investigación, Universidad Autónoma del Perú, Lima, 150142, Perú.ORCID 0000-0001-6694-7991
Cesar Augusto Roque-BordaSchool of Pharmacy, Biochemistry and Biotechnology, Santa Maria Catholic University (UCSM), Arequipa, 04013, Perú.ORCID 0000-0002-9262-0383
Jessica Ingrid Marquez CazorlaSchool of Pharmacy, Biochemistry and Biotechnology, Santa Maria Catholic University (UCSM), Arequipa, 04013, Perú.ORCID 0000-0003-3736-1654
Renzo Marianito Marquez CazorlaSchool of Pharmacy, Biochemistry and Biotechnology, Santa Maria Catholic University (UCSM), Arequipa, 04013, Perú.ORCID 0000-0002-9202-6202
Uner Josseph Pinto ApazaSchool of Pharmacy, Biochemistry and Biotechnology, Santa Maria Catholic University (UCSM), Arequipa, 04013, Perú.ORCID 0009-0008-7809-2976
Vanderson de Jesus SilvaTuberculosis Research Laboratory, School of Pharmaceutical Science, São Paulo State University (UNESP), Araraquara, 14800-903, Brazil.ORCID 0009-0000-6482-6678
Laura Maria Duran Gleriani PrimoTuberculosis Research Laboratory, School of Pharmaceutical Science, São Paulo State University (UNESP), Araraquara, 14800-903, Brazil.ORCID 0000-0003-2752-9302
Maura Jennifer Martínez-MoralesLaboratoire de Chimie des Polymères Organiques, Université de Bordeaux, Bordeaux, 33000, France.ORCID 0000-0003-2009-3622
Rafael Miguel SábioTuberculosis Research Laboratory, School of Pharmaceutical Science, São Paulo State University (UNESP), Araraquara, 14800-903, Brazil.ORCID 0000-0002-3852-2184
Hélder A SantosDepartment of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, Groningen, 9713 AV, The Netherlands.ORCID 0000-0001-7850-6309
Fernando Rogério PavanTuberculosis Research Laboratory, School of Pharmaceutical Science, São Paulo State University (UNESP), Araraquara, 14800-903, Brazil.ORCID 0000-0002-6969-3963

Funding

Productivity Research Fellows (PQ CNPq) 303603/2018-6São Paulo Research Foundation (FAPESP) #2020/16573-3São Paulo Research Foundation (FAPESP) #2023/01664-1UMCG Research Funds
6 · The paper itself

Abstract

Gastrointestinal infections, which are caused primarily by pathogenic bacteria, remain a significant global health challenge. Their resilience is reinforced by various physical, biological, and biopharmaceutical barriers that complicate conventional therapeutic strategies. This review delves into the intricate landscape of managing these infections, addressing microbiota imbalances, the emergence of multidrug-resistant strains, and the impact of dysbiosis and antibiotic overuse. Faced with these challenges, traditional therapies often fail, which is hindered by low bioavailability, prolonged regimens, and a growing risk of resistance. In this context, nanotechnology applied to antimicrobial peptides (AMPs) has emerged as a promising solution to enhance their stability and targeted delivery. Through a critical approach, diverse nanocarriers and their efficacy against intestinal pathogens are evaluated both in vitro and in vivo. This review advocates for intensified research on the encapsulation and functionalization of AMPs, envisioning their potential to redefine the control of intestinal infections on a global scale.

Indexed as

Antimicrobial PeptidesGastrointestinal TractNanotechnologyAnimalsHumansAntimicrobial Peptidesantimicrobial peptidegastrointestinal infectionsmultidrug resistancenanocarriersnanoparticles

Identifiers

PMID40384187
PMCPMC12232244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.