Evidence mapPaperPMID 40384889Full record

ArticleJCEM case reports2025

Cystic Fibrosis and Hemochromatosis Carriers May Be Prone to Glucagon-like Peptide-1 Agonist Pancreatitis: 3 Cases.

Guy Itzhak Sydney, Tammy Do, William Austin West, Gabriel Ikponmosa Uwaifo

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guy Itzhak SydneySection of Endocrinology, Yale School of Medicine, New Haven, CT 06510, USA.ORCID https://orcid.org/0000-0001-9336-3350
Tammy DoDept of Medicine, Ochsner Medical Center, New Orleans, LA 70121, USA.
William Austin WestSection of Pulmonology and Critical Care, University of Southern California Medical Center, Los Angeles, CA 90333, USA.
Gabriel Ikponmosa UwaifoDivision of Endocrinology, Department of Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.ORCID https://orcid.org/0000-0002-6962-9304

Funding

DIABETES MELLITUS &DISORDERS OF METABOLISMT32DK007058 · YALE UNIVERSITY · 1986 to 2025
$2.2M
NIDDK NIH HHS T32 DK007058
6 · The paper itself

Abstract

Glucagon-like peptide-1 (GLP-1) agonists are widely used in the management of type 2 diabetes and obesity, with their therapeutic scope expanding to address cardiometabolic and cardiorenal conditions. However, their increasing use has been associated with potential adverse effects, including acute pancreatitis (AP). The exact prevalence of GLP-1 agonist-induced AP remains uncertain and reliable predictors for its onset have yet to be identified. We present 3 cases of class-associated predilection for GLP-1 analog-associated AP in patients with carrier states for hemochromatosis (HC) and cystic fibrosis. Case 1 is a heterozygous carrier for the

Indexed as

acute pancreatitischronic pancreatitiscystic fibrosisGLP-1 agonistshemochromatosisheterozygous carrier

Identifiers

PMID40384889
PMCPMC12078934

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.