Evidence mapPaperPMID 40385122Full record

ArticleInternational journal of ophthalmology2025

Combining orbital intensity modulated radiation therapy with periorbital triamcinolone acetonide injection for Graves' orbitopathy.

Huan Jian, Rui-Xin Ma, Wei-Min He

Abstract read
In one paragraph

Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Huan JianDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Rui-Xin MaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Wei-Min HeDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the efficacy of combined orbital radiation and periorbital triamcinolone acetonide injection for patients with Graves' orbitopathy (GO) who experienced treatment failure with glucocorticoid pulse therapy (GPT).

methodsA total of 57 eligible patients (35.09% males, mean age of 51.19±11.90y) were included in this case-series study. The medical information collected during each visit was evaluated and analyzed.

resultsSignificant improvement was observed in patients six months after radiation therapy. Both the clinical activity score and the efficacy score showed substantial improvement (

conclusionThe combination therapy demonstrates significant effectiveness in treating patients with GO who experienced severe ocular inflammation and have previous GPT failure. Noticeable improvement is observed as early as one month after initiating radiation therapy, and patients with more severe inflammatory states showes greater benefit from the treatment.

Indexed as

glucocorticoid pulse therapyGraves'orbital radiationorbitopathyperiorbital injectionthyroid ophthalmopathy

Identifiers

PMID40385122
PMCPMC12043304

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.