Evidence map›Paper›PMID 40385161›Full record

ArticleACS omega2025

One Strain Many Compounds Approach for Anti-

Beatriz A Andrade, Augusto L Dos Santos, Dayana A S Ferreira, Mariana B Abiuzi, Daniel P Vieira, Marina M Gonçalves, João Henrique G Lago, Patricia Sartorelli, Andre G Tempone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Beatriz A AndradePathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.
Augusto L Dos SantosInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Diadema Campus, São Paulo, SP 09913-030, Brazil.
Dayana A S FerreiraPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.
Mariana B AbiuziPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.
Daniel P VieiraLab de Radiobiologia do Centro de Biotecnologia - CEBIO (IPEN-CNEN/SP), Av. Lineu Prestes 2242, Cidade Universitária, São Paulo, SP 05508-000, Brazil.
Marina M GonçalvesCentre of Natural Sciences and Humanities, Universidade Federal do ABC, Sao Paulo 09210-580, Brazil.
João Henrique G LagoCentre of Natural Sciences and Humanities, Universidade Federal do ABC, Sao Paulo 09210-580, Brazil.ORCID https://orcid.org/0000-0002-1193-8374
Patricia SartorelliInstituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Diadema Campus, São Paulo, SP 09913-030, Brazil.ORCID https://orcid.org/0000-0002-1624-8145
Andre G TemponePathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.ORCID https://orcid.org/0000-0003-2559-7344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neglected tropical diseases as Chagas disease (CD) affect more than eight million people, mainly in the Americas, causing fatal cardiovascular outcomes. Relying on two old, toxic, and low efficacy drugs for treatment, there is an urgent need for new candidates. Comprising a high chemodiversity, marine bacteria are a rich source of small molecules with potential against human pathogens. Cultivation-based strategies of bacteria, such as the one strain many compounds (OSMAC) approach, have proven to be a simple and promising tool for drug discovery, with the ability to stimulate the expression of cryptic genes in microorganisms. In this study, using the OSMAC, we evaluated the potential of the marine bacteria

Identifiers

PMID40385161
PMCPMC12079262

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.