Evidence map›Paper›PMID 40385278›Full record

ArticleCardiovascular diagnosis and therapy2025

Apolipoprotein M delays the development of atherosclerosis by regulating autophagy and mitochondrial function.

Yuanping Shi, Shuang Yao, Binhua Jiang, Jun Zhang, Mingjun Cao, Jing Wu, Lu Zheng, Ning Xu, Xiaoying Zhang, Guanghou Shui and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diagnosis and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuanping ShiClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Shuang YaoClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Binhua JiangLipidall Technologies Company Limited, Changzhou, China.
Jun ZhangClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Mingjun CaoInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Jing WuClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Lu ZhengClinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Ning XuSection of Clinical Chemistry and Pharmacology, Institute of Laboratory Medicine, Lunds University, Lund, Sweden.
Xiaoying Zhang *Department of Cardiothoracic Surgery, the Third Affiliated Hospital of Soochow University, Changzhou, China.
Guanghou Shui *Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Guanghua Luo *Clinical Medical Research Center, the Third Affiliated Hospital of Soochow University, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Apolipoprotein M (ApoM), a protein component of lipoproteins, is closely related to the development of atherosclerosis, but the specific mechanism remains elusive. Mitochondrial DNA damage can contribute to atherosclerosis, so this study was designed to investigate whether ApoM influences the structure and function of mitochondria during the progression of atherosclerosis and to explore the underlying mechanism. Methods: Atherosclerosis models were established in male ApoM-deficient ( Results: In Conclusions: ApoM exerts atheroprotective effects by promoting autophagy and regulating mitochondrial dynamics, thereby maintaining mitochondrial integrity and function. This study provides novel insights into the mechanisms underlying the protective role of ApoM in atherosclerosis and highlights its potential as a therapeutic target for cardiovascular diseases.

Indexed as

Apolipoprotein M (ApoM)atherosclerosisautophagylipid metabolismmitochondria

Identifiers

PMID40385278
PMCPMC12082226

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.