ArticlemedRxiv : the preprint server for health sciences2025
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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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132 authors.
Jesper Qvist ThomassenDepartment of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID 0000-0003-3484-9531
Leonard HamptonCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0003-2390-8110
Brittany UlmsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Benjamin Grenier-BoleyUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID 0009-0004-3412-3997
Sami HeikkinenInstitute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.ORCID 0000-0002-6083-2402
Pablo GarciaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.ORCID 0000-0003-0125-5403
Atahualapa Castillo-MoralesUK Dementia Research Institute, School of Medicine, Cardiff University, Wales, UK.
Masataka KikuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Japan.ORCID 0000-0002-9562-841X
Jungsoo GimDepartment of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.ORCID 0000-0002-6454-9751
Han CaoDivision of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.ORCID 0000-0001-9992-9108
Fahri KüçükaliVIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID 0000-0002-3835-9639
Najaf AminNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-8944-1771
Dabin YoonDepartment of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.
Itziar de RojasAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.ORCID 0000-0002-2148-381X
Pilar Alvarez JerezCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0002-5812-1898
Victoria AlvarezLaboratorio de Genética. Hospital Universitario Central de Asturias, Oviedo, Spain.
Beatrice ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.ORCID 0000-0002-0615-3580
Celine BellenguezUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID 0000-0002-1240-7874
Sverre BerghThe Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.ORCID 0000-0001-9593-2967
Kimberly BillingsleyCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0002-6554-0476
Cornelis BlauwendraatCoalition for Aligning Science, 5425 Wisconsin Ave #600, Chevy Chase, MD 20815, USA.ORCID 0000-0001-9358-8111
Merce BoadaAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.ORCID 0000-0003-2617-3009
Barbara BorroniDepartment of Clinical and Experimental Sciences, University of Brescia, Italy.ORCID 0000-0001-9340-9814
Paola BossùLaboratory of Experimental Neuropsychobiology, Clinical Neuroscience and Neurorehabilitation Department, IRCCS Santa Lucia Foundation, Rome, Italy.
María J BullidoNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Antonio DanieleDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0003-1641-5852
Ángel CarracedoGrupo de Medicina Xenómica, CIBERER, CIMUS. Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Alexandre de MendonçaFaculty of Medicine, University of Lisbon, Portugal.ORCID 0000-0002-0488-1453
Mark CooksonCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0002-1058-3831
Jürgen DeckertDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Germany.ORCID 0000-0003-1008-4650
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-8140-8061
Oriol Dols-IcardoNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0003-2656-8748
Carole DufouilUniversity of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France.ORCID 0000-0003-2442-4476
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Valentina Escott-PriceUKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0003-1784-5483
Tormod FladbyInstitute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.ORCID 0000-0002-9984-9797
Laura FratiglioniKarolinska University Hospital, Theme inflammation and Aging, Sweden.
Amy K Y FuDivision of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.ORCID 0000-0003-4085-6201
Daniela GalimbertiNeurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.ORCID 0000-0002-9284-5953
Jose Maria García-AlbercaCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.
Guillermo Garcia-RibasHospital Universitario Ramon y Cajal, IRYCIS, Madrid.
Caroline GraffKarolinska University Hospital, Theme inflammation and Aging, Sweden.ORCID 0000-0002-9949-2951
Timo GrimmerCenter for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
Edna GrünblattDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
OIivier HanonUniversité Paris Cité, EA 4468, APHP, Hospital Broca, Memory Resource and Research Centre of de Paris-Broca-Ile de France, Paris, France.ORCID 0000-0002-4697-122X
Lucrezia HausnerDepartment of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Germany.
Stefanie Heilmann-HemibachInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Jakub HortMemory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Czech Republic.
Frank JessenDepartment of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Kendall JensenCenter for Noninvasive Diagnostics, TGen, Phoenix, AZ, USA.ORCID 0000-0001-8833-6323
Caroline JonsonCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0001-7049-6281
Yoontae KimWell-aging Medicare Institute & CSU G-LAMP Project Group, Chosun University, Gwangju, 61452, Republic of Korea.
Nicole KuznetsovCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0009-0005-9847-0282
Ville LeinonenDepartment of Neurosurgery, Kuopio University Hospital, Puijonlaaksontie 2 FI-70210 Kuopio, Finland.ORCID 0000-0002-4282-4687
Anssi LipponenInstitute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.ORCID 0000-0002-4403-9084
Jiao LuoDepartment of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID 0000-0001-8511-8945
Mary MakariousCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0002-7978-1051
Henna MartiskainenInstitute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.ORCID 0000-0003-2796-1859
Carlo MasulloInstitute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.ORCID 0000-0001-7798-3410
Patrizia MecocciDivision of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Italy.ORCID 0000-0003-0729-5246
Shima MehrabianClinic of Neurology, UH "Alexandrovska", Medical University - Sofia, Sofia, Bulgaria.ORCID 0000-0002-3146-6001
Pablo MirNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0003-1656-302X
Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Japan.
Susanne MoebusInstitute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.
Kin Y MokDivision of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Laura Molina PorcelNeurological Tissue Bank - Biobanc- Hospital Clinic -IDIBAPS, Barcelona, Spain.
Fermin MorenoNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Benedetta NacmiasDepartment of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy.ORCID 0000-0001-9338-9040
Lucilla ParnettiCentre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.ORCID 0000-0001-5722-3967
Pau PastorFundació Docència i Recerca MútuaTerrassa, Terrassa, Barcelona, Spain.ORCID 0000-0002-7493-8777
Jordi Pérez-TurNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-9111-1712
Oliver PetersGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Yolande A L PijnenburgAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Gerard Piñol-RipollUnitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
Julius PoppOld Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.
Innocenzo RaineroDepartment of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.ORCID 0000-0001-6074-9628
Luis M RealUnidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, Spain.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany.
Eloy Rodriguez-RodriguezNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0001-7742-677X
Arvid RongveHaugesund Hospital, Department of Research and Innovation, Haugesund, Norway.ORCID 0000-0002-0476-4134
Giacomina RossiUnit of Neurology V - Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.ORCID 0000-0001-6680-2725
Jose Luis RoyoDepatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina. Universidad de Málaga. Málaga, Spain.ORCID 0000-0003-2024-4363
Dan RujescuDepartment of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria.ORCID 0000-0002-1432-313X
Ingvild SaltvedtDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID 0000-0002-7897-9808
María Eugenia SáezCAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
Raquel Sánchez-ValleAlzheimer's disease and other cognitive disorders unit. Service of Neurology. Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
Florentino Sanchez-GarciaDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.
Nicolai SandauDepartment of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID 0000-0002-1941-097X
Nikolaos ScarmeasTaub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, Columbia University, New York, NY.
Katja SchefflerDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.ORCID 0000-0002-1734-7807
Norbert ScherbaumDepartment of Psychiatry and Psychotherapy, LVR-Klinikum Essen, University of Duisburg-Essen, Germany.
Anja SchneiderGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Geir SelbækNorwegian National Advisory Unit on Aging and Health, Vestfold Health Trust, Tønsberg, Norway.ORCID 0000-0001-6511-8219
Davide SeripaDepartment of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.ORCID 0000-0001-7331-0470
Vincenzo SolfrizziInterdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, University of Bari "A. Moro, Bari, Italy.ORCID 0000-0002-8524-0315
Marco SpallazziDepartment of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy.ORCID 0000-0002-8091-2063
Alessio SquassinaDepartment of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.ORCID 0000-0001-7415-7607
Eystein StordalNamsos Hospital, Namsos, Norway.ORCID 0000-0002-2443-7923
Niccoló TesiAmsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
Lucio TremolizzoNeurology Unit, IRCCS "San Gerardo dei Tintori", Monza, Italy.ORCID 0000-0003-0473-6560
Kumar P TripathiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3998-599X
Wiesje M van der FlierAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.ORCID 0000-0001-8766-6224
Julie WilliamsUK Dementia Research Institute, School of Medicine, Cardiff University, Wales, UK.
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
Dag AarslandDepartment of Old Age Psychiatry, Division of Academic Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.ORCID 0000-0001-6314-216X
Andrew B SingletonCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0001-5606-700X
Philippe AmouyelUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID 0000-0001-9088-234X
Stéphanie DebetteUniversity of Bordeaux, Inserm Bordeaux Population Health Research Center U1219, Bordeaux, France.ORCID 0000-0001-8675-7968
Gael NicolasUniv Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and Reference Center for Developmental Disorders, Rouen, France.ORCID 0000-0001-9391-7800
Sven van der LeeAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.ORCID 0000-0003-1606-8643
Henne HolstegeAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.ORCID 0000-0002-7688-3087
Maria Victoria FernandezAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.ORCID 0000-0002-9669-5147
Patrick Gavin KehoeBristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-7542-1139
Kristel SleegersVIB Center for Molecular Neurology, VIB, Antwerp, Belgium.ORCID 0000-0002-0283-2332
Martin IngelssonDepartment of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-5466-8370
Roberta GhidoniMolecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.ORCID 0000-0002-7691-1957
Ole A AndreassenCentre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Peter A HolmansDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.ORCID 0000-0003-0870-9412
Pascual Sánchez-JuanNetworking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Rebecca SimsDivision of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.ORCID 0000-0002-3885-1199
Nancy Y IpDivision of Life Science, State Key Laboratory of Molecular Neuroscience and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.ORCID 0000-0002-2763-8907
Kun Ho LeeDepartment of Biomedical Science, Chosun University, Gwangju, 61452, Republic of Korea.
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Japan.ORCID 0000-0001-8828-8085
Alfredo RamirezGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Agustin RuizAce Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.ORCID 0000-0003-2633-2495
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.ORCID 0000-0003-3566-4096
Jean-Charles LambertUniversité de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.ORCID 0000-0003-0829-7817
Cornelia van DuijnNuffield Department of Population Health, University of Oxford, Oxford, UK.
Mike NallsCenter for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0003-0319-4325
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID 0000-0003-4084-5027
Funding
STRIDESOT2OD027852 · OD · FOUR POINTS TECHNOLOGY, LLC · PI Joel A Lipkin · 2018 to 2026
$255.6MSTRIDES OT2OD027060 · OD · CARAHSOFT TECHNOLOGY CORPORATION · PI Terry Drinkwine · 2018 to 2026
$134.1MNIH STRIDES - Azure and Associated Services and Training.OT2OD032100 · OD · DELL FEDERAL SYSTEMS L.P. · PI Amy K HammondOdwyer, Erum Siddiqui · 2021 to 2026
$62.2MNIH HHS OT2 OD027060NIH HHS OT2 OD027852NIH HHS OT2 OD032100
Abstract
Among the more than 90 identified genetic risk loci for late-onset Alzheimer's disease (AD) and related dementias, the apolipoprotein E gene (
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What Socratic holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.