Evidence map›Paper›PMID 40385437›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Deep learning-based polygenic scores enhance generalizability of psychiatric disorders prediction.

Leonardo Cobuccio, Arnor I Sigurdsson, Kajsa-Lotta Georgii Hellberg, Morten Dybdahl Krebs, Jonas Meisner, iPSYCH Study Consortium, Thomas Werge, Michael E Benros, Andrew J Schork, Simon Rasmussen

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leonardo CobuccioNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Arnor I SigurdssonNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Kajsa-Lotta Georgii HellbergInstitute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Morten Dybdahl KrebsInstitute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Jonas MeisnerNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
iPSYCH Study Consortium
Thomas WergeInstitute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Michael E BenrosCopenhagen Research Centre for Mental Health, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
Andrew J SchorkInstitute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, DK-4000 Roskilde, Denmark.
Simon RasmussenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Funding

Improving the interpretability of genetic studies of major depressive disorder to identify risk genesR01MH130581 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONATHAN FLINT, KENNETH SEEDMAN KENDLER · 2022 to 2026
$2.8M
NIMH NIH HHS R01 MH130581
6 · The paper itself

Abstract

Polygenic scores (PGSs) have emerged as promising tools for predicting complex traits from genetic data, however, their predictive performance for psychiatric disorders remains limited and the added value of deep learning (DL) over linear models is underexplored. In this study, we compared our DL model, Genome-Local-Net (GLN), with the linear model bigstatsr in predicting five psychiatric disorders-ADHD, ASD, BIP, MDD, and SCZ-using individual-level genotype data. We further assessed whether combining these

Identifiers

PMID40385437
PMCPMC12083566

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.