ArticleJournal of diabetes and metabolic disorders2025
Effects of multi-strain synbiotic supplementation on liver enzymes, insulin resistance, anthropometric, and inflammatory indices in overweight and obese adults with fatty liver and diabetes: a randomized controlled trial.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effects of a Plant-Based Multi-StrainNutrients · 2026Trial
- Hepatogenous diabetes in the era of precision medicine: diagnosis, management, and future directions.Clinical and experimental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Synbiotic supplements have been shown to affect type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), however; results remain inconclusive. Thus, the present study was designed to investigate the potential effect of multi-strain synbiotic supplements on liver enzymes, insulin resistance, anthropometric indices, and inflammatory markers in overweight/obese patients with NAFLD and T2DM. Method: In a 12-week triple-blinded randomized controlled trial, 40 eligible overweight or obese adults with NAFLD and T2DM were randomly assigned to two groups to consume either synbiotic supplements or a placebo along a low-calorie diet. Participants were assessed for liver enzymes, anthropometric and glycemic indices, and lipid profiles before and after the study. Result: After the study period, using intention-to-treat approach 20 individuals were included in the final analysis for each group. The intervention group showed significant reductions in within group analysis for insulin levels, weight, and BMI ( Conclusion: In the present study, synbiotic supplements showed improvements in insulin levels, weight, BMI, and AST. However, in comparison to the control group no beneficial effects were observed. Further studies are recommended to draw more definitive conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.