ReviewCureus2025
Bexagliflozin on Renal Outcomes in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium-glucose cotransporter-2 (SGLT2) inhibitors are important for treating type 2 diabetes mellitus (T2DM). However, it remains unclear whether the newest SGLT2 inhibitor, bexagliflozin, provides benefits for renal- or urinary-related outcomes. The ClinicalTrials.gov, PubMed, Embase, and Cochrane databases were searched for randomized controlled trials. Using R software version 4.3.1 (R Foundation for Statistical Computing, Vienna, Austria), a random-effects model was employed to compute mean differences (MD) and risk ratios for continuous and binary endpoints. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to rate the certainty of evidence. The International Prospective Register of Systematic Reviews (PROSPERO) identification number is CRD42023478336. Nine studies involving 4,352 patients were included. Over a follow-up that ranged from 12 to 96 weeks, patients taking bexagliflozin showed no changes in serum creatinine levels (MD: 0.05 mg/dL; 95% CI: -0.06 to 0.15; p = 0.35) or estimated glomerular filtration rate (MD: -0.43 mL/min/1.73 m
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.