ArticleJournal of inflammation research2025
Association Between Lactate Dehydrogenase/Albumin Ratio and in-Hospital Mortality in Patients with Acute Aortic Dissection.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Evaluation of Systemic Inflammatory Indices in Pregnant Women With Deep Vein Thrombosis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
- Association of lactate dehydrogenase to albumin ratio with new-onset acute respiratory distress syndrome and all-cause mortality in patients with sepsis: a retrospective cohort study based on the MIMIC-IV database.BMC infectious diseases · 2026Article
- Relationship Between Cumulative Exposure of Lactate Dehydrogenase Concentrations and Major Adverse Cardiac and Cerebrovascular Events in Hypertensive Patients: A Retrospective Cohort Study from Northwest China.Journal of inflammation research · 2026Article
- Elevated novel inflammatory markers in heart failure patients are associated with increased risk of adverse outcomes within one year: insights from a longitudinal study.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
6 authors.
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Abstract
Background: Previous studies have identified the lactate dehydrogenase/albumin ratio (LAR) as an independent prognostic marker, significantly predicting in-hospital mortality in patients with inflammation and cancer. Building on this, the current study is designed to explore the association between LAR and mortality during hospitalization in patients with acute aortic dissection (AAD). Methods: This retrospective study included patients diagnosed with AAD between January 1, 2010, and March 1, 2023. Patients were categorized into three groups based on LAR tertiles: T1 (<5.01), T2 (5.01-6.43), and T3 (>6.43). Multivariable logistic regression analysis was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). In addition, subgroup analysis, receiver operating characteristic (ROC) curves, decision curve analysis (DCA), clinical impact curve analysis, Boruta algorithm, and the Kaplan-Meier analysis were applied to analyze the data. Results: A total of 2083 patients were enrolled in the study, with an average age of 53.20 ± 12.35 years, and male patients constituted 77%. After adjusting for relevant variables, ORs for in-hospital mortality were found to be 2.12 (95% CI: 1.34-3.36, p=0.001) for T2 and 2.30 (95% CI: 1.44-3.68, p<0.001) for T3, compared to T1. The ROC curve, DCA analysis, Boruta algorithm, and Kaplan-Meier analysis demonstrated that the LAR exhibited a high level of concordance and practical applicability in forecasting in-hospital mortality. Conclusion: Elevated LAR is significantly associated with an increased risk of in-hospital mortality in patients with AAD. The results indicate that LAR may serve as a valuable predictor of adverse outcomes during hospitalization for these patients.
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