Evidence map›Paper›PMID 40386213›Full record

ArticleFrontiers in nutrition2025

Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice.

Jiacheng Fang, Xiaochen Zhang, Zhongshi Qi, Liying Zhou, Yuntiao Chen, Qingxin Li, Run Liu, Hongzhuan Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiacheng Fang *Weifang Hospital of Traditional Medicine, Affiliated Traditional Chinese Medicine of Shandong Second Medical University, Weifang, Shandong, China.
Xiaochen Zhang *Department of International Management, Business School, The University of Adelaide, Adelaide, SA, Australia.
Zhongshi QiSchool of Public Health, Qingdao University, Qingdao, Shandong, China.
Liying ZhouSchool of Public Health, Qingdao University, Qingdao, Shandong, China.
Yuntiao ChenSchool of Public Health, Qingdao University, Qingdao, Shandong, China.
Qingxin LiSchool of Public Health, Qingdao University, Qingdao, Shandong, China.
Run LiuSchool of Public Health, Qingdao University, Qingdao, Shandong, China.
Hongzhuan YuWeifang Hospital of Traditional Medicine, Affiliated Traditional Chinese Medicine of Shandong Second Medical University, Weifang, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Diabetic cognitive dysfunction (DCD) refers to the impairment of cognitive function resulting from diabetes. The increasing prevalence of diabetes and the aging population have rendered DCD a significant threat to brain health. Young apple polyphenol extract (YAPE) has demonstrated potential in preventing DCD, although its underlying mechanism remains incompletely understood. Therefore, this study aims to investigate the preventive efficacy and underlying mechanisms of YAPE on DCD. Methods: Streptozotocin-induced diabetic mice were randomly divided into four groups ( Results: Following a 14-weeks intervention, disrupted cognitive function and neuronal apoptosis were observed in DM group, both of which were effectively restored by YAPE supplementation through improving ten-eleven translocation protein 2 (TET2)-mediated active DNA demethylation. Moreover, YAPE supplementation enhanced TET2 protein stability by activating phosphorylated AMP-activated protein kinase (AMPK) and improved TET enzyme activity by upregulating α-ketoglutarate/(succinic acid + fumaric acid) ratio, subsequently enhancing TET2 function. Discussion: Consequently, YAPE effectively delays progression from diabetes to DCD by facilitating TET2-mediated active DNA demethylation.

Indexed as

active DNA demethylationdiabetic cognitive dysfunctionmitochondrionten-eleven translocation protein 2young apple polyphenol extract

Identifiers

PMID40386213
PMCPMC12081242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.